Results 81 to 90 of about 5,093,417 (249)

CP-EXCEL:  A feasibility randomised controlled trial of an online exercise programme for adults with cerebral palsy [version 3; peer review: 2 approved]

HRB Open Research
Introduction Adults with cerebral palsy (CP) are at increased risk of non-communicable diseases and often experience secondary complications as they age. Physical activity can mitigate these risks and improve well-being.
Karen McConnell, Rebecca Walters, Aisling Walsh, Éabha Wall, Claire Kerr, Claire Kenny, Kevin Bravender, Jessica Burke, Rachel Byrne, Jennifer Ryan, Fiona Weldon, Pauline Hunter-Graham, Manjula Manikandan, Miriam Creeger, Ailish McGahey   +14 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

“They are nae worrying about it… so …what’s the point in asking?”: A qualitative study of candidacy for early CKD care in areas of multiple deprivation

BMC Nephrology
Background Chronic kidney disease (CKD) is common, associated with substantial comorbidity and strong socioeconomic gradients. Early CKD care focuses on preventing disease progression and reducing cardiovascular risk. However, inequities in access to CKD
Buse Keskindag, Tom Blakeman, Audrey Hughes, Samira Bell, Mike Melvin, Fumiko Nakamaru, Melany Gray, Bhautesh Jani, Mhairi Mackenzie, Nicole Scholes-Robertson, Eilidh Cowan, Paul Cockwell, Simon Sawhney, Magdalena Rzewuska Diaz   +13 more
doaj   +1 more source

The 20 m shuttle run is not a valid test of cardiorespiratory fitness in boys aged 11–14 years

BMJ Open Sport & Exercise Medicine, 2019
Objectives The 20 m shuttle run test (20mSRT) is used to estimate cardiorespiratory fitness (CRF) through the prediction of peak oxygen uptake (V˙O2), but its validity as a measure of CRF during childhood and adolescence is questionable.
Jo Welsman, Neil Armstrong
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Understanding the role of patient and public involvement in renal dietetic research [PDF]

, 2017
The objective was to consult patients on a proposed recruitment strategy to a patient and public involvement exercise. We wanted to explore the reasoning and willingness of patients to become co-researchers within a grant application.
Biggerstaff, Deborah, Krishnan, Nithya, Lycett, Deborah, Morris, Andrew, Mr   +3 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Does a Screening Trial for Spinal Cord Stimulation in Patients with Chronic Pain of Neuropathic Origin have Clinical Utility and Cost-Effectiveness? (TRIAL-STIM Study): study protocol for a randomised controlled trial

Trials, 2018
Background The TRIAL-STIM Study aims to assess the diagnostic performance, clinical outcomes and cost-effectiveness of a screening trial prior to full implantation of a spinal cord stimulation (SCS) device.
Sam Eldabe, Ashish Gulve, Simon Thomson, Ganesan Baranidharan, Rui Duarte, Susan Jowett, Harbinder Sandhu, Raymond Chadwick, Morag Brookes, Anisah Tariq, Jenny Earle, Jill Bell, Anu Kansal, Shelley Rhodes, Rod S. Taylor   +14 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source