Results 51 to 60 of about 440,904 (297)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
An evidence-based method for assessing the value of a search tool: a pilot study
Journal of the Medical Library Association, 2018 Objective: The objective of this study was to develop an evidence-based method with a set of metrics that could be used to assess an information search tool.
Donald Stanley Pearson +2 more
doaj +1 more source
Sub genomic analysis of SARS-CoV-2 using short read amplicon-based sequencing
Frontiers in Genetics, 2023 The novel coronavirus disease 2019 (COVID-19) pandemic poses a serious public health risk. In this report, we present a modified sequencing workflow using short tiling (280bp) amplicons library preparation method paired with Illumina’s iSeq100 desktop ...
Lian Chye Winston Koh +11 more
doaj +1 more source
Campbell Systematic ReviewsThis is the protocol for a Campbell systematic review. The main objective of this realist review is to gather, critically appraise, and synthesize evidence to identify what works, for whom, in what circumstances, and how non‐familial intergenerational ...
Lysha Z. Y. Lee +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The Healthy Part of the Hospital : A Qualitative Interview Study on Users and Librarians’ Views on Patient Libraries [PDF]
, 2018 The aim for this master’s thesis is to clarify users’ and librarians’ views on patient libraries today. This aim is achieved by answering the following research questions: Which are the most important functions and tasks of the patient library, according
Karlsson, Kristin
core
The patient-driven Rare Disease Research Network: turning research on its head
BMJ OpenBackground The vast majority of healthcare research in the UK is investigator-led. While national progress in patient and public involvement (PPI) increasingly mandates patient consultation, research questions and outcomes still frequently misalign with ...
Rona M Smith +6 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
RRH Library Newsletter, March 2014 [PDF]
, 2014 Newsletter sections include: Human Trafficking -- Modern Day Slavery; Patient Library Merger; STAT!Ref ...
Libraries at Rochester Regional Health
core +1 more source
The awareness and utilization levels of bibliotherapy by medical and library personnel in Yaba Psychiatric Hospital, Lagos Nigeria [PDF]
, 2008 This paper presents the findings of a study that examined the awareness and utilization levels of bibliotherapy by medical and library personnel in Yaba Psychiatric Hospital, Lagos, Nigeria.
S N Anasi, Anasi, S N
core +1 more source