Results 71 to 80 of about 440,904 (297)

Establishing and Maintaining an Extensive Library of Patient-Derived Xenograft Models

Frontiers in Oncology, 2018
Patient-derived xenograft (PDX) models have recently emerged as a highly desirable platform in oncology and are expected to substantially broaden the way in vivo studies are designed and executed and to reshape drug discovery programs.
Marissa Mattar, Craig R. McCarthy, Amanda R. Kulick, Besnik Qeriqi, Sean Guzman, Elisa de Stanchina   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Arte contemporáneo y participación: la reflexión y el diálogo como generadores de distracción positiva [PDF]

, 2012
So We could say that social relationships in hospital are very restrictive. They are always around illness. This article try to describe two different experiences taken place in Children Oncological room and Dialysis treatment room in Hospital Gregorio ...
G. Cano, Marta; Universidad de Complutense de Madrid.
core   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Bibliotherapy: Patient Libraries and Reading Programs, One Component of the Moral Treatment Revolution [PDF]

, 2007
OBJECTIVES: We will examine the utilization of bibliotherapy in 19th century psychiatric “asylums” focusing on two respected institutions; Butler Hospital and Worcester State Hospital as well as the writings of their respective superintendents, Isaac Ray
Levin, Len L, Gildea, Ruthann
core   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Modeling and Optimization of Individualized Liver Contrast-enhanced CT Imaging [PDF]

, 2023
More than half of clinical CT imaging in the United States involves the use of iodinated contrast materials. The use of such contrast agents in CT imaging enhances tissue contrast, particularly in soft tissue organs such as the liver, pancreas, spleen ...
Setiawan, Hananiel
core  

Addressing the needs and identifying supports for parents of chronically ill adolescents and young adults in their shared transition from paediatric to adult care: a scoping review protocol

BMJ Open
Introduction The transition from paediatric to adult healthcare marks a pivotal period for chronically ill adolescents, as they transition from a highly supportive and family-oriented environment to an adult-oriented and a more individual-oriented ...
Kate Murray, Karen Frost, Samantha K Micsinszki, Pranshu Maini, Claudia Tersigni, Sarah Cairns   +5 more
doaj   +1 more source

Hospital patient libraries andinformation services in Australia [PDF]

Australian Health Review, 2001
In order to find out how many and what kind of Hospital Patient Libraries exist in Australia I placed a "Request for Information" on our national electronic discussion list entitled 'aliaHealth'. This discussion list has presently nearly 300 subscribers.
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source