Results 61 to 70 of about 440,904 (297)

Mixed-methods study protocol to develop and pilot a Competency Assessment Tool to support therapists in the care of patients with blunt CHest trauma (CATCh study)

BMJ Open
Introduction Competency assessment tools are well-recognised as a method to achieve a standardised level of practice for a group of healthcare professionals with similar characteristics.
Ceri Battle, Jane Barnett, E Baker, Timothy Driscoll, Hayley Anne Hutchings, Claire O’Neill, Hannah Toghill, Rhys Whelan   +7 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Umanizzare la salute : i libri, l’arte e le relazioni come supporto terapeutico [PDF]

, 2002
In this document three initiatives are illustrated about "humanizing" health, developed at Centro di Riferimento Oncologico di Aviano (Pordenone, Italy), one of the seven Italian oncological IRCCS: the Patient library, Art as therapeutical support ...
Vicario, Gianni, Ciolfi, Laura, Merighi, Roberta, Seroppi, Paola, Cannizzaro, Renato, Biancat, Roberto, Zotti, Paola, Annunziata, Maria Antonietta, Truccolo, Ivana, Piani, Barbara, Ricci, Roberto, Parpinel, Maria, Bidoli, Ettore, Capello, Fabia   +13 more
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Interprofessional clinical reasoning education [PDF]

Clinical reasoning is considered one of the most important competencies but is not included in most healthcare curricula. The number and diversity of patient encounters are the decisive factors in the development of clinical reasoning competence ...
Gögenur, Ismaïl, Eriksen, Thomas
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Blood-Bourne MicroRNA Biomarker Evaluation in Attention-Deficit/Hyperactivity Disorder of Han Chinese Individuals: An Exploratory Study [PDF]

, 2018
Background: Attention-deficit/hyperactivity disorder (ADHD) is a highly genetic neurodevelopmental disorder, and its dysregulation of gene expression involves microRNAs (miRNAs).
Miao-Chun Chou, Sung-Chou Li, Lien-Hung Huang, Min-Jing Lee, Wen-Jiun Chou, Liang-Jen Wang, Chih-Wei Hsu, Ho-Chang Kuo, Sheng-Yu Lee   +8 more
core   +1 more source

Azalea : un sistema di conoscenza in oncologia a disposizione di pazienti e cittadini. Roma, 16 giugno 2005 [PDF]

, 2005
Azalea. An oncology knowledge system aimed at patients and the public. Proceedings of the conference held 16 June 2005 at the Regina Elena Cancer Institute, Rome, on the inauguration of the Digital Library – Knowledge Centre “R Maceratini” and the ...

core   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

La Biblioteca de Pacientes del Hospital Virgen de la Victoria de Málaga [PDF]

, 2016
Patient Library Hospital Virgen de la Victoria in Malaga, presents its history of almost thirty years. A public library in which his will and broad public hospital service.
Garcia Ballesteros, María Teresa
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