Results 91 to 100 of about 2,861,427 (316)

Time to deterioration of patient-reported outcome endpoints in cancer clinical trials: targeted literature review and best practice recommendations

Journal of Patient-Reported Outcomes
Background Time to deterioration (TTD) endpoints are often utilized in the analysis of patient-reported outcome (PRO) data in oncology clinical trials but different endpoint definitions and analysis frameworks exist that can impact result interpretation.
Kim Cocks, Bellinda L. King-Kallimanis, Joel Sims, Gill Worthy, Julia Stein, Lara Ayala–Nunes, Monika Achra, Zhanglin Lin Cui, Nalin Payakachat   +8 more
doaj   +1 more source

Patient and clinician opinions of patient reported outcome measures (PROMs) in the management of patients with rare diseases: a qualitative study

Health and Quality of Life Outcomes, 2020
Background Rare diseases may be life-threatening or chronically debilitating conditions. Patient care needs are often complex and challenging to coordinate and deliver effectively.
Olalekan Lee Aiyegbusi, Fatima Isa, Derek Kyte, Tanya Pankhurst, Larissa Kerecuk, James Ferguson, Graham Lipkin, Melanie Calvert   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Defining Patient-Reported Outcomes

Value in Health, 2004
This paper considers and defines the different types of patient-reported outcomes that can be collected in clinical studies. In particular, it argues that quality of life (QoL) is a distinctly different type of outcome from Health-Related Quality of Life (HRQL).
Doward, Lynda C., McKenna, Stephen P.
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Defining Patient Experience [PDF]

, 2014
In recent years, perceptions of performance and quality of healthcare organizations have begun to move beyond examining the provision of excellent clinical care, alone, and to consider and embrace the patient experience as an important indicator.
LaVela, Sherri L., PhD, MPH, MBA, Marshburn, Dianne, PhD, RN, NE-BC, Niederhauser, Victoria, DrPH, RN, Wolf, Jason A, PhD, CPXP   +3 more
core   +2 more sources

Patient-Reported Outcomes (PROs) and Patient-Reported Outcome Measures (PROMs).

Health services insights, 2013
In recent years, there has been an increased focus on placing patients at the center of health care research and evaluating clinical care in order to improve their experience and ensure that research is both robust and of maximum value for the use of medicinal products, therapy, or health services.
Welding, Theresa, Smith, Sheree M. (R16768)   +1 more
openaire   +3 more sources

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Evaluation and measurement of patient experience [PDF]

, 2014
Despite the increasing presence of a variety of measures of patient health care experiences in research and policy, there remains a lack of consensus regarding measurement.
LaVela, Sherri L., PhD, MPH, MBA, Gallan, Andrew S., PhD   +1 more
core   +2 more sources