Results 101 to 110 of about 2,861,427 (316)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Understanding side effects of therapy for myasthenia gravis and their impact on daily life

BMC Neurology, 2019
Background Myasthenia gravis is a chronic, autoimmune, neuromuscular junction disorder characterized by skeletal muscle weakness. Current therapies for myasthenia gravis are associated with significant side effects.
Elizabeth Dansie Bacci, Karin S. Coyne, Jiat-Ling Poon, Linda Harris, Audra N. Boscoe   +4 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Patterns and clinical outcomes of lithium treatment [PDF]

, 2008
Patterns and consequences of lithium use’. In chapter 2.1 we studied lithium use patterns in out-patients within the last decade. In line with the increase in alternatives and the Dutch guidelines, we observed an increase in use of atypical ...
Wilting, I., Dep Farmaceutische wetenschappen, Population-based studies of drug treatment: from molecule to patient outcomes   +2 more
core  

The outcome of the geriatric patients in the ICU [PDF]

Critical Care, 2001
The aim of the study was to compare the outcome of the geriatric patients (≥ 65 years of age; Group 1) with young ones (< 65 years of age; Group 2), and to compare the outcome of the elderly patients (65–74 years of age; Group A) with the very old ones (≥ 75 years of age; Group B) in the intensive care unit (ICU).
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Effect of Hospital Nurse Staffing on Patient Health Outcomes: Evidence from California's Minimum Staffing Regulation [PDF]

Hospitals are currently under pressure to control the cost of medical care, while at the same time improving patient health outcomes. These twin concerns are at play in an important and contentious decision facing hospitals—choosing appropriate nurse ...
Andrew Cook, Lowell Taylor, Melvin Stephens, Jr., Martin Gaynor   +3 more
core  

Instrument development and evaluation for patient-related outcomes assessments [PDF]

, 2012
Małgorzata Farnik, Władysław PierzchałaDepartment of Pneumonology, Silesian University of Medicine, Katowice, PolandAbstract: Patient-related outcomes measures could provide important information for the current state of the art in medical care and even ...
Farnik M, Pierzchała W
core  

Investigating organizational quality improvement systems, patient empowerment, organizational culture, professional involvement and the quality of care in European hospitals: the 'Deepening our Understanding of Quality Improvement in Europe (DUQuE)' project. [PDF]

, 2010
BACKGROUND: Hospitals in European countries apply a wide range of quality improvement strategies. Knowledge of the effectiveness of these strategies, implemented as part of an overall hospital quality improvement system, is limited.
Andrew Thompson, Klazinga, Niek, Arah Onyebuchi A, Suñol, Rosa, Arah, O.A., Groene Oliver, Klazinga Niek, Charles Bruneau, Thompson, Andrew, Cordula Wagner, Klazinga, N., Groene, O., Wagner, C., Wagner, Cordula, Suñol Rosa, Arah, Onyebuchi A.., Onyebuchi A Arah, Arah, O. A., Thompson Andrew, Rosa Suñol, Deepening our Understanding of Quality Improvement in Europe Res, Sunol, R., Arah, Onyebuchi A, ?, ?, Niek Klazinga, null null, Oliver Groene, Bruneau, Charles, Wagner Cordula, Bruneau Charles, Arah, Onyebuchi A., Groene, Oliver, Suñol Sala, Rosa, Bruneau, C., Thompson, A.   +34 more
core   +1 more source