Results 31 to 40 of about 2,539,328 (219)

The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Combined oral contraceptive (COC) use in obese adult women dramatically increases the relative risk of developing a pulmonary embolism (PE). The risk of a PE in obese adolescent females taking contraceptives is currently unknown. The purpose of this investigation was to determine the effect of body mass index (BMI) and contraceptive
John Puetz, Joanne Salas
wiley   +1 more source

A generic and adaptable model of developing, implementing, and maintaining patient-reported outcomes in clinical practice – the AmbuFlex model

Journal of Patient-Reported Outcomes
Background Patient-reported outcomes (PROs) are aspects of health status reported directly by patients. Over the last decade, PROs have been increasingly used in clinical practice.
Liv Marit Valen Schougaard, Anne Jessen, Anne Treschow Phillipsen, Anke de Beijer, Camilla Buur Udbye Agesen, Helle Dahl Harbo, Jonas Hermann Schrøder, Kathrine Hønholt Carlson, Katja Kimose Sloth, Lene Bjerre Graakjaer, Louise Pape Larsen, Mette Roost, Nanna Toxvig Sørensen, Regine Grytnes, Sanne Degn Gjørup, Sidse Østergaard Olesen, Birgith Engelst Grove   +16 more
doaj   +1 more source

Development and evaluation of the Acromegaly Symptom Diary

Journal of Patient-Reported Outcomes, 2023
Background Patient-reported outcome (PRO) measures are important to consider when evaluating treatments, yet there are no PRO measures for patients with acromegaly that have been developed in accordance with US Food and Drug Administration guidance ...
Susan Martin, Randall H. Bender, Alan Krasner, Tonya Marmon, Michael Monahan, Lauren Nelson   +5 more
doaj   +1 more source

Chronic rhinosinusitis with nasal polyps (CRSwNP) symptom verbal response scales: content validity testing for use in adults with CRSwNP

Journal of Patient-Reported Outcomes
Background PRO measures of symptoms in clinical trials have historically utilized visual and numerical scales but verbal descriptors may make it easier for patients to clearly differentiate between response options.
Tom Keeley, Nina Gaw, Waseem Ahmed, Rafael Alfonso-Cristancho, Ana R. Sousa, Katie Forde, Rosie Sharp, Sophie Whyman, Adam Gater   +8 more
doaj   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source

Health-related quality of life burden of nonalcoholic steatohepatitis: a robust pragmatic literature review

Journal of Patient-Reported Outcomes, 2018
Objective Nonalcoholic steatohepatitis (NASH) is a form of chronic liver disease (CLD): patients have an increased risk of developing cirrhosis, liver failure, and complications (e.g. hepatocellular carcinoma). NASH has a high clinical burden, and likely
Tessa Kennedy-Martin, Jay P. Bae, Rosirene Paczkowski, Emily Freeman   +3 more
doaj   +1 more source

What motivates patients and caregivers to engage in health research and how engagement affects their lives: Qualitative survey findings

Health Expectations, 2020
Background US research organizations increasingly are supporting patient and stakeholder engagement in health research with a goal of producing more useful, relevant and patient‐centered evidence better aligned with real‐world clinical needs. The Patient‐
Rachel Hemphill, Laura P. Forsythe, Andrea L. Heckert, Andrew Amolegbe, Maureen Maurer, Kristin L. Carman, Rikki Mangrum, Lisa Stewart, Ninma Fearon, Laura Esmail   +9 more
doaj   +1 more source

Health funders’ dissemination and implementation practices: results from a survey of the Ensuring Value in Research (EViR) Funders’ Forum

Implementation Science Communications, 2022
Background A significant gap persists between evidence from research and its use in practice. Research funders, important actors in the health research system, can help reduce this gap by initiating dissemination and implementation (D&I) activities.
Barbara van der Linden, Kelly M. Dunham, Joanna Siegel, Emily Lazowick, Michael Bowdery, Tara Lamont, Alison Ford   +6 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Symptom burden and health-related quality of life impacts of smoldering multiple myeloma: the patient perspective

Journal of Patient-Reported Outcomes, 2020
Background Smoldering multiple myeloma (SMM) is an early form of multiple myeloma (MM). SMM is typically considered asymptomatic, and research on how it affects health-related quality of life (HRQoL) is limited. This study assessed the symptoms and HRQoL
Milenka Jean-Baptiste, Katharine S. Gries, William R. Lenderking, John Fastenau   +3 more
doaj   +1 more source