Results 91 to 100 of about 760,216 (304)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Evaluating patient participation in value-based healthcare: Current state and lessons learned. [PDF]

Health Expect
Introduction Value‐based healthcare (VBHC) focusses on increasing value for patients. Hospitals aim to implement VBHC via value improvement (VI) teams for medical conditions.
Westerink HJ, Garvelink MM, van Uden-Kraan CF, Zouitni O, Bart HAJ, van der Wees PJ, van der Nat PB, Santeon Patient Participation Study Group.   +7 more
europepmc   +2 more sources

The Information Flow in a Healthcare Organisation with Integrated Units

International Journal of Integrated Care, 2019
Introduction: Integrated care is believed to provide support to patients with multiple long-term and complex conditions. Transparency in information delivery is key for shared decision-making, and co-production of care.
Åsa Kneck, Maria Flink, Oscar Frykholm, Marie Kirsebom, Mirjam Ekstedt   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

So much more than a “pair of brown shoes”: Triumphs of patient and other stakeholder engagement in patient-centered outcomes research

, 2015
This piece illustrates the “real world” experiences of patients and other stakeholder partners in research to help inform and inspire future patient-centered outcomes research (PCOR) efforts.
Kratchman, Amy, Norton, M.A., Christine K., Brodt, M.P.P., Amanda   +2 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The psychological effects of research participation on people with dementia: findings from a German exploratory interview study

Frontiers in Dementia
The German National Dementia Strategy aims to engage people with dementia in research projects. However, the effects of such research participation on experience and behavior have been insufficiently explored.
Katja Seidel, Katja Seidel, Claudia Winiarski, Jochen René Thyrian, Jochen René Thyrian, Julia Haberstroh   +5 more
doaj   +1 more source

Shared decision-making in Israel: status, barriers, and recommendations

Israel Journal of Health Policy Research, 2012
Shared decision making (SDM) - involving patients in decisions relevant to their health - has been increasingly influential in medical thought and practice around the world.
Miron-Shatz Talya, Golan Ofra, Brezis Mayer, Siegal Gil, Doniger Glen M   +4 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Involvement of patients or their representatives in quality management functions in EU hospitals:implementation and impact on patient-centred care strategies [PDF]

, 2014
OBJECTIVE: The objective of this study was to describe the involvement of patients or their representatives in quality management (QM) functions and to assess associations between levels of involvement and the implementation of patient-centred care ...
Kristensen, S, Ommen, O, Pfaff, H, Bottaro, S., Kringos, D.S., Wang, A., Lívio, A., Shaw, C., Plochg, T, Kristensen, S., Depaigne-Loth, A., Depaigne-Loth, A, Kutaj-Wasikowska, H, Kus, H, Secanell, M., Mannion, Russell, Ozturk, K., Bruneau, Charles, Leite, I, Botje, D, Groene, Oliver, Kutryba, B, Saillour-Glenisson, F, Garel, Pascal, Almeman, F., Lívio, A, Eiras, M, Wang, A, Franca, M, Thompson, Caroline A., Saluvan, M, Hammer, A., Almeman, F, Bartels, Paul, Jones, S., Kringos, DS, Secanell, M, Groene, O., Garel, P, Dersarkissian, Maral, Groene, O, Sunol, R., Kutaj-Wąsikowska, Halina, Leite, I., Lopez, MA, Arah, OA, Botje, Daan, Suñol Sala, Rosa, Thompson, Caroline A, Wagner, C, Kus, H., Vlcek, Frantisek, Klazinga, N. S., Franca, M., Escoval, Ana, Sunol, R, Plochg, T., Jones, S, Thompson, A, Car, M., DUQuE Project Consortium, Klazinga, Niek S, Wang, Aolin, Lombarts, M.J.M.H., Escoval, A, Eiras, M., Wagner, Cordula, Bartels, P, Chow, A., Shaw, C, Arah, Onyebuchi A, DerSarkissian, M, ?, ?, Klazinga, N, Klaus, E, Arah, Onyebuchi A., Bruneau, C, Vallejo, P., Thompson, A., Kutryba, B., Lombarts, MJMH, Car, M, Sunol, Rosa, Vlcek, F, Ommen, O., Saluvan, M., Thompson, CA, Klaus, E., Bottaro, S, Thompson, Andrew, Saillour-Glenisson, F., Vallejo, P, Lopez, M. A., Klazinga, Niek S., Mannion, R, Michel, P, Arah, Onyebuchi A.., Ozturk, K, Pfaff, H., Universitat Autònoma de Barcelona, Hammer, A, Michel, P.   +101 more
core   +1 more source