Results 131 to 140 of about 1,321,475 (298)

Organizing for Higher Performance: Case Studies of Organized Delivery Systems [PDF]

, 2009
Offers lessons learned from healthcare delivery systems promoting the attributes of an ideal model as defined by the Fund: information continuity, care coordination and transitions, system accountability, teamwork, continuous innovation, and easy ...
Douglas McCarthy, Kimberly Mueller
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

How patient-reported outcomes and experience measures (PROMs and PREMs) are implemented in healthcare professional and patient organizations? An environmental scan

Journal of Patient-Reported Outcomes
Background Patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) are becoming essential parts of a learning health system, and using these measures is a promising approach for value-based healthcare. However, evidence
Véronique Lowry, Vanessa Tremblay-Vaillancourt, Priscilla Beaupré, Marie-Dominique Poirier, Marie-Ève Perron, Jessica Bernier, Anaëlle Morin, Caroline Cormier, Jeannie Haggerty, Sara Ahmed, Magaly Brodeur, Geneviève David, Sylvie Lambert, Maude Laberge, Diana Zidarov, Regina Visca, Thomas G. Poder, Hervé Tchala Vignon Zomahoun, Maxime Sasseville, Marie-Eve Poitras   +19 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Exploring content and psychometric validity of newly developed assessment tools for itch and skin pain in atopic dermatitis. [PDF]

, 2019
BackgroundAtopic dermatitis (AD) is a common skin disorder characterized by chronic inflammation, altered skin barrier function, and inflammatory cell skin infiltration that decreases health-related quality of life (HRQoL).
Abetz-Webb, Linda, DeLozier, Amy M, Eichenfield, Lawrence F, Gable, Jonathon C, Griffiths, Philip C, Hill, Jennifer N, Hudgens, Stacie, Newton, Louise, Paik, Jim, Silverberg, Jonathan I, Symonds, Tara, Wyrwich, Kathleen W   +11 more
core  

The Association Between Patient-Reported Experience Measures and Patient-Reported Outcome Measures Among Patients With Diabetes in the Kingdom of Saudi Arabia

Value in Health Regional Issues
OBJECTIVES: This study investigated the association between patient-reported experience measures (PREMs) and patient-reported outcome measures (PROMs) among patients with diabetes in the Kingdom of Saudi Arabia. METHODS: This quantitative cross-sectional study was conducted on 594 patients with diabetes from July to August 2023 at all primary ...
Alsubahi, Nizar, Pavlova, Milena, Alzahrani, Ahmed Ali, Ahmad, Ala'eddin, Groot, Wim   +4 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Using patient-generated health data more efficient and effectively to facilitate the implementation of value-based healthcare in the EU – Innovation report

Computational and Structural Biotechnology Journal
Healthcare services and products are rapidly changing due to the development of new technologies, offering relevant solutions to improve patient outcomes.
Frans Folkvord, Jim Ingebretsen Carlson, Manuel Ottaviano, Diego Carvajal, Liss Hernandez Gonzalez, Rens van de Schoot, Eva Turk, Jordi Piera-Jiménez, Caridad Pontes, Marina Ramiro-Pareta, Gerard Carot-Sans, Eva Podovšovnik, Vesna Levašič, Kathrin Scheckenbach, Martin Wagenmann, Aron Szpisjak, Bogi Eliasen, Joe-Max Wakim, Martin Ernst, Yvonne Prinzellner, Nadine Bol, Linwei He, Emiel Krahmer, Clàudia Navarro, Laia Juan, Davide Guerri, Laura Pinna, Carmela Genovese, Luciano Benetti, Chiara Macagnano, Franco Chiarugi, Johannes Peeters, Ludovico Pedullà, Giampaolo Brichetto, Paola Zaratin, Seldag Gunes Peschke, Lutz Peschke, Giuseppe Fico   +37 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

International cross-cultural development and field testing of the primary care practice questionnaire for the PaRIS survey (PaRIS-PCPQ)

BMC Primary Care
Background The PaRIS survey, an initiative of the Organisation for Economic Co-operation and Development (OECD), aims to assess health systems performance in delivering primary care by measuring the care experiences and outcomes of people over 45 who ...
Janika Bloemeke-Cammin, Oliver Groene, Marta Ballester, Frederico Guanais, Peter Groenewegen, Candan Kendir, Ian Porter, Amun Rehsi, Mieke Rijken, Peter Spreeuwenberg, Rosa Suñol, Jose Maria Valderas, Rachel Williams, Michael van den Berg   +13 more
doaj   +1 more source