Results 121 to 130 of about 16,816,868 (338)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Ocena stopnia poinformowania oraz wiedzy pacjentów na temat badania elektroencefalograficznego = Evaluation level of information and knowledge of patients about the study electroencephalographic

Journal of Education, Health and Sport, 2015
Zych Justyna, Skonieczna Joanna, Olejniczak Dominik, Zakrzewska Karolina. Ocena stopnia poinformowania oraz wiedzy pacjentów na temat badania elektroencefalograficznego = Evaluation level of information and knowledge of patients about the study ...
Justyna Zych, Joanna Skonieczna, Dominik Olejniczak, Karolina Zakrzewska   +3 more
doaj  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Legal provision for the rights of persons who receive rehabilitation assistance

Bulletin of Kharkiv National University of Internal Affairs
The research is devoted to the problems of legal provision of the rights of persons who receive rehabilitation assistance. The author examines the norms of international and national legislation that enshrine the rights of citizens in the field of ...
O. A. Ivakhnenko, A. M. Glushchenko, O. V. Novykov   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Oncologists' reflections on patient rights and access to compassionate use drugs: A qualitative interview study from an academic cancer center. [PDF]

PLoS One, 2021
Stout J, Smith C, Buckner J, Adjei AA, Wentworth M, Tilburt JC, Master Z.   +6 more
europepmc   +1 more source

Study of Awareness of Patients’ Rights among Under-Graduate Medical Students

, 2018
Ramnika Aggarwal, Sumita Sethi, Renu Garg, Rajesh Kumar   +3 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Patients’ Attitude toward Breaking Bad News; a Brief Report

Emergency, 2016
Introduction: Delivering bad news is a stressful moment for both physicians and patients. The purpose of this investigation was to explore the patients’ preferences and attitudes toward being informed about the bad news.
Hamed Aminiahidashti, Seyed Jaber Mousavi, Mohammad Mehdi Darzi   +2 more
doaj