Results 191 to 200 of about 4,628,126 (296)

Probing Immune Signatures of Conjugated Pattern Recognition Receptor Ligands Identifies Chimeras with Potent Adjuvant and Antitumor Activities. [PDF]

J Med Chem
Janež Š, Guzelj S, Weiss V, Šišić M, Frkanec R, Pajk S, Burgmeijer L, Slütter B, Jakopin Ž.   +8 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Elongator is required for pattern recognition receptor and type I interferon signaling in macrophages. [PDF]

J Biol Chem
Murphy J, Baran M, Grünke C, Haas D, Barber G, Pichlmair A, Bowie AG.   +6 more
europepmc   +1 more source

Regulation of Pattern-Recognition Receptor Signaling by HBX During Hepatitis B Virus Infection. [PDF]

Front Immunol, 2022
You H, Qin S, Zhang F, Hu W, Li X, Liu D, Kong F, Pan X, Zheng K, Tang R.   +9 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation. [PDF]

Eur J Immunol
Ntita M, Kong CSL, Hassan D, Nayak R, García JP, Wang Y, Chen J, Evans SE.   +7 more
europepmc   +1 more source

The Pattern Recognition Receptor FLS2 Can Shape the Arabidopsis Rhizosphere Microbiome β-Diversity but Not EFR1 and CERK1. [PDF]

Plants (Basel), 2022
Fonseca JP, Lakshmanan V, Boschiero C, Mysore KS.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Innate immune recognition and microenvironmental reprogramming in HPV-induced cervical cancer: from pattern recognition receptor activation to immune tolerance disruption. [PDF]

Front Cell Infect Microbiol
Khan SU, Halawi MH, Almehmadi M, Taha R, Ahmed AE, Alfaifi MY, Shati AA, Elbehairi SEI, Ahmad S, Alanazi YF, Al-Rasheed M, Pandupuspitasari NS, Widiastuti E, Khan MU.   +13 more
europepmc   +1 more source

The Arabidopsis pattern recognition receptor EFR enhances fire blight resistance in apple. [PDF]

Hortic Res, 2021
Piazza S, Campa M, Pompili V, Costa LD, Salvagnin U, Nekrasov V, Zipfel C, Malnoy M.   +7 more
europepmc   +1 more source