Results 261 to 270 of about 4,628,126 (296)

Visualising pattern recognition receptor signalling

Biochemical Society Transactions, 2017
Signalling by pattern recognition receptors (PRRs) is critical for protecting the host against pathogens. Disruption of these signalling pathways has been implicated in many diseases ranging from infection susceptibility to cancer and autoimmune disease.
Charlotte, Macleod, Clare E, Bryant
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Pattern-recognition Receptors in Pulp Defense

Advances in Dental Research, 2011
Initial sensing of infection is mediated by germline-encoded pattern-recognition receptors (PRRs), the activation of which leads to the expression of inflammatory mediators responsible for the elimination of pathogens and infected cells. PRRs act as immune sensors that provide immediate cell responses to pathogen invasion or tissue injury.
M-J, Staquet, F, Carrouel, J-F, Keller, C, Baudouin, P, Msika, F, Bleicher, T A, Kufer, J-C, Farges   +7 more
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Identification and functions of pattern-recognition receptors

Journal of Allergy and Clinical Immunology, 2010
Since the identification of Toll-like receptors, our knowledge about pattern-recognition receptors (PRRs) has increased rapidly. Classes of PRRs that have been recently discovered include RIG-I-like receptors, Nod-like receptors, and C-type lectin receptors.
Yutaro, Kumagai, Shizuo, Akira
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Pattern recognition receptor function in neutrophils

Trends in Immunology, 2013
Previously, neutrophils were largely ignored in the pattern recognition receptor (PRR) signaling field. However, interest in neutrophil biology has been revitalized by emerging roles for neutrophils in promoting protective and pathogenic T helper (Th)17-driven immune responses and in orchestrating innate and adaptive immunity via cytokine/chemokine ...
Thomas, Christina J., Schroder, Kate
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Expression of pattern recognition receptors in cholesteatoma

European Archives of Oto-Rhino-Laryngology, 2013
Although many immunologic mechanisms have been investigated in studies of the pathogenesis of cholesteatoma, the role of pattern recognition receptors (PRRs) has not been fully determined. Therefore, we assessed innate immune responses in patients with cholesteatoma. We prospectively evaluated 21 patients with acquired cholesteatoma between August 2010
Ho Yun, Lee, Moon Suh, Park, Jae Yong, Byun, Young Il, Kim, Seung Geun, Yeo   +4 more
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Pattern Recognition by Toll-like Receptors

2009
The mammalian immune system senses pathogens through pattern recognition receptors and responds with activation. The Toll-like receptors (TLRs) that are expressed on antigen presenting cells such as macrophages and dendritic cells play a critical role in this process.
Stefan, Bauer, Thomas, Müller, Svetlana, Hamm   +2 more
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Pattern Recognition Receptors in Plant Immunity

Plant innate immunity is an advanced defense system to counteract pathogenic stresses. It relies on the recognition of microbial invasion through cell surface-localized pattern recognition receptors (PRRs) and intracellular nucleotide-binding domain leucine-rich repeat receptors (NLRs).
Mughair, Abdul Aziz, Azra, Shamim, Khaled, Masmoudi   +2 more
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Pattern Recognition by NOD-Like Receptors

Nucleotide-binding oligomerization domain-like receptors (NLRs) are a family of cytosolic pattern recognition receptors (PRRs) and able to respond to conserved microbe-associated molecular patterns (MAMPs) and endogenous damage-associated molecular patterns (DAMPs).
Timo-Daniel, Voss, Lucy, Hezinger, Thomas A, Kufer   +2 more
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Therapeutic targeting of pattern-recognition receptors

International Immunopharmacology, 2006
Innate immune system could recognize the pathogen-associated molecular patterns by pattern-recognition receptors like Toll-like receptor (TLR) and nucleotide-binding oligomerisation domain (NOD) protein. Information regarding the structure and signalling pathways of TLRs and NODs could provide opportunities for new therapeutic approaches to modulate ...
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Pattern Recognition Receptors in Autoinflammation

2019
The immune system is essential for maintenance of tissue homeostasis. This task requires that immune cells detect and respond to dyshomeostatic states (when homeostasis has broken down) that can occur during invasion of the host with pathogenic microbes, after sterile trauma of tissues or during metabolic derangements.
Saavedra, Victor, Moghaddas, Fiona, Latz, Eicke, Masters, Seth L.   +3 more
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