Results 101 to 110 of about 476,732 (307)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Spatial Analysis of a mixed Beech, Spruce and Fir stand in the Eastern Alps [PDF]

, 2010
In a forest reserve, located in the Eastern Italian Alps, a 4 ha permanent plot has been set up in a beech-spruce-fir multilayered forest, left to natural evolution for more than 30 years, in order to detect stand structure and spatial patterns ...
Marin, Alberto
core  

Self-Assembly of Fine Particles on Patterned Wettability in Dip Coating and Its Scale Extension with Contact Printing

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2008
This study demonstrates the application of dip coating to self-assembly of fine particles on a substrate that is covered with line-and-space pattern of hydrophilic (SiO2) and hydrophobic materials (OTS).
Yoshihito KANAMORI, Arata KANEKO, Nobuyuki MORONUKI, Takafumi KUBO   +3 more
doaj   +1 more source

Hsichengia: A 4,6-connected trigonal structural pattern in space group P3m1

Russian Journal of General Chemistry, 2009
A novel 4,6-connected network, called Hsichengia, is described. The novel network lies in the trigonal space group P3m1 (no. 156), with a = b = 3.447 A and c = 12.948 A; these lattice parameters were derived assuming Fe-S composition. It implies a binary AB2 stoichiometry in which the 6-connected A (Fe) atoms have octahedral configuration, and the 4 ...
Bucknum, Michael J., Castro, Eduardo Alberto   +1 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Pattern Space of Evolutionarily Stable Strategies

, 1997
A conflict is defined by a set of pure strategies f1; : : : ; ng and a payoff matrix, and may have many Evolutionarily Stable Strategies (ESSs). A set of subsets of the set of pure strategies is called a pattern.
M. Broom
core  

Thermally Induced Oscillations of an Inflatable Space Structure with a Repeated Element Pattern

The International Journal of Acoustics and Vibration, 2011
One of the most important environmental disturbances is thermal loading. There are three known sources of radiation in space environment: (1) direct solar, (2) earth solar reflection (albedo), and (3) direct earth (infrared). The effects of the last two are less significant for orbits higher than the LEO orbit. When a satellite goes through an eclipse,
Armaghan Salehian, Daniel J. Inman
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Compressed Multiple Pattern Matching [PDF]

, 2019
Given d strings over the alphabet {0,1,...,sigma{-}1}, the classical Aho - Corasick data structure allows us to find all occ occurrences of the strings in any text T in O(|T| + occ) time using O(m log m) bits of space, where m is the number of edges in ...
Kosolobov, Dmitry, Sivukhin, Nikita, Sivukhin, N., Kosolobov, D.   +3 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source