Results 111 to 120 of about 536,532 (302)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Structural analysis of ZrO2 and TiO2 nanoparticles

Научно-технический вестник информационных технологий, механики и оптики
The constituent parts of systems where radiation-catalytic processes occur usually differ in terms of mass and electron density, structural characteristics, electrophysical and chemical properties.
G. Imanova
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

COLONIAL AND TRADITIONAL URBAN SPACE IN JAVA: A MORPHOLOGICAL STUDY OF TEN CITIES

Dimensi: Journal of Architecture and Built Environment, 2013
Most of morphological studies of cities in Java tended to place the elements of traditional urban space – such as Alun-alun, Mosque, Palace and Market – as the main elements of city.
SUNARYO Rony Gunawan, SOEWARNO Nindyo, Ikaputra Ikaputra, SETIAWAN Bakti   +3 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Defined types of cortical interneurone structure space and spike timing in the hippocampus

Journal of Physiology, 2005
P. Somogyi, T. Klausberger
semanticscholar   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

An IPv6 target generation approach based on address space forest

Scientific Reports
IPv6 target generation techniques are crucial for Internet-wide rapid scanning of IPv6 network assets. Current algorithms are mostly limited to low-dimensional patterns (pattern dimensions $$\le$$  4) within the IPv6 address space tree (6ASTree).
Shunlong Hao, Liancheng Zhang, Hongtao Zhang, Lanxin Cheng, Yi Guo, Zhanbo Li, Bin Lin, Haojie Zhu, Mingyue Ren, Lanyun Zhang   +9 more
doaj   +1 more source

Multivariate autoregressive modelling of sea level time series from TOPEX/Poseidon satellite altimetry [PDF]

Nonlinear Processes in Geophysics, 2006
This work addresses the autoregressive modelling of sea level time series from TOPEX/Poseidon satellite altimetry mission. Datasets from remote sensing applications are typically very large and correlated both in time and space.
S. M. Barbosa, M. E. Silva, M. J. Fernandes   +2 more
doaj