Results 111 to 120 of about 2,846,227 (302)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The Risk and Return of Venture Capital [PDF]
This paper measures the mean, standard deviation, alpha and beta of venture capital investments, using a maximum likelihood estimate that corrects for selection bias.
John H. Cochrane
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Macroeconomic fluctuations and the firms' rate of growth distribution: evidence from UK and US quoted companies [PDF]
We fit the asymmetric Subbotin distribution introduced by Bottazzi and Secchi (2003) on UK and US data on quoted companies, in order to detect sources of asymmetries in the transmission of aggregate shocks, and cyclical patterns of higher moments of the ...
Emiliano Santoro
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Control-Group Feature Normalization for Multivariate Pattern Analysis Using the Support Vector Machine [PDF]
, 2015 Normalization of feature vector values is a common practice in machine learning. Generally, each feature value is standardized to the unit hypercube or by normalizing to zero mean and unit variance.
Davatzikos, Christos +4 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Deviating from the standard: effects on labor continuity and career patterns
, 2006 Deviating from a standard career path is increasingly becoming an option for individuals to combine paid labor with other important life domains. These career detours emerge in diverse labor forms such as part-time jobs, temporary working hour reductions, and labor force time-outs, used to alleviate conflicting time demands throughout careers ...
openaire +1 more source
Measuring gini coefficient of education: the Indonesian cases [PDF]
While income inequality in third world countries has aggressively been commented and studied extensively, little analysis is relatively available on measuring inequality in other dimensions of human development.
Digdowiseiso, Kumba
core +1 more source