Results 51 to 60 of about 146,603 (293)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Evaluation of Performance and Challenges of Use of Waste Materials in Pavement Construction: A Critical Review

open access: yesApplied Sciences, 2019
Paved surfaces must reliably bear heavy loads, often under challenging environmental and geotechnical conditions. These requirements are addressed through the use of high-quality, newly produced materials in pavement design. However, in remote locations,
Ali Jamshidi, Greg White
doaj   +1 more source

Evaluation of pavement service life using AASHTO 1972 and mechanistic-empirical pavement design guides

open access: yesInternational Journal of Transportation Science and Technology, 2023
Service life is often used by state transportation agencies to evaluate alternative flexible pavement designs. The design that keeps the pavement in acceptable condition longest before it needs another maintenance treatment is the preferred design. For a
Fahim Ahmed   +4 more
doaj   +1 more source

Marquette Interchange Phase I Final Report [PDF]

open access: yes, 2007
This report provides details on the design, installation and monitoring of a pavement instrumentation system for the analysis of load-induced stresses and strains within a perpetual HMA pavement system.
Crovetti, James   +3 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Mixture Strength Class and Slab Dimensions’ Effect on The Precast Concrete Pavement Structural Performance

open access: yesThe Baltic Journal of Road and Bridge Engineering, 2019
Mechanical properties and slab dimensions of concrete are the major parameters based on which the performance of concrete pavement structures is predicted.
Audrius Vaitkus   +3 more
doaj   +1 more source

Perpetual Pavement Instrumentation for the Marquette Interchange Project-Phase 1 [PDF]

open access: yes, 2007
This report provides details on the design, installation and monitoring of a pavement instrumentation system for the analysis of load-induced stresses and strains within a perpetual HMA pavement system.
Crovetti, James   +3 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Performance Evaluation of JPCP with Changes of Pavement Mix Design Using Pavement Management Data

open access: yesAdvances in Civil Engineering, 2019
This study aimed to analyze long-term performance of JPCP (jointed plain concrete pavement) according to changes in standard mix design using evaluation of concrete properties based on Korea HPMS (highway pavement management system) and Korea LTPP (long ...
Han Jin Oh   +4 more
doaj   +1 more source

Effects of Orientations, Aspect Ratios, Pavement Materials and Vegetation Elements on Thermal Stress inside Typical Urban Canyons [PDF]

open access: yes, 2019
The analysis of local climate conditions to test artificial urban boundaries and related climate hazards through modelling tools should become a common practice to inform public authorities about the benefits of planning alternatives. Different finishing
Acero, J.A.   +5 more
core   +3 more sources

Home - About - Disclaimer - Privacy