Results 51 to 60 of about 178 (122)

Biphenotypic Sinonasal Sarcoma With a Novel PAX3::MAML2 Fusion

Genes, Chromosomes and Cancer, Volume 65, Issue 7, July 2026.
ABSTRACT Biphenotypic sinonasal sarcoma (BSNS) is a rare, low‐grade spindle cell sarcoma of the sinonasal tract. It is characterized by dual neural and myogenic differentiation and classically shows fusions involving PAX3. MAML3, a co‐activator in the Notch signaling pathway, is the most common fusion partner of PAX3.
Mayu Uemura, Anna Fong Na Goh, Amit Kumar, Gary Quagliotto, Pranav Dorwal   +4 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, Volume 600, Issue 9, Page 1265-1287, May 2026.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Clinicopathological Characteristics and Outcomes of Genitourinary Rhabdomyosarcoma in Two Girls

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Rhabdomyosarcoma (RMS) is a soft tissue neoplasm accounting for about 8% of solid tumors in children. There are mainly four histologic subtypes of RMS: embryonal, alveolar, spindle cell/sclerosing, and pleomorphic. The genitourinary tract is the second most affected primary site of RMS. Genitourinary RMS is more common in young boys than girls.
George Evele, Francine Kouya, George Ngock, Richard Bardin   +3 more
wiley   +1 more source

The PAX3-FOXO1 oncogene alters exosome miRNA content and leads to paracrine effects mediated by exosomal miR-486

Scientific Reports, 2019
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. The alveolar subtype (ARMS) is clinically more aggressive, and characterized by an oncogenic fusion protein PAX3-FOXO1 that drives oncogenic cellular properties.
Farah Ghamloush, Sandra E. Ghayad, Ghina Rammal, Assil Fahs, Abeer J. Ayoub, Zeina Merabi, Mohamad Harajly, Hassan Zalzali, Raya Saab   +8 more
doaj   +1 more source

Hyper-activation of Notch3 amplifies the proliferative potential of rhabdomyosarcoma cells.

PLoS ONE, 2014
Rhabdomyosarcoma (RMS) is a pediatric myogenic-derived soft tissue sarcoma that includes two major histopathological subtypes: embryonal and alveolar.
Maria De Salvo, Lavinia Raimondi, Serena Vella, Laura Adesso, Roberta Ciarapica, Federica Verginelli, Antonio Pannuti, Arianna Citti, Renata Boldrini, Giuseppe M Milano, Antonella Cacchione, Andrea Ferrari, Paola Collini, Angelo Rosolen, Gianni Bisogno, Rita Alaggio, Alessandro Inserra, Mattia Locatelli, Stefano Stifani, Isabella Screpanti, Lucio Miele, Franco Locatelli, Rossella Rota   +22 more
doaj   +1 more source

The Role of Polyphenols in Regulating Skeletal Muscle Development and Homeostasis: Molecular Mechanisms and Potential Medical Applications

Molecular Nutrition &Food Research, Volume 70, Issue 8, 27 April 2026.
Graphical abstract describes the impact of polyphenols on signal transduction pathways involved in the development, differentiation and regeneration of muscle tissue. ABSTRACT A healthy lifestyle, characterized by moderate physical activity, appropriate caloric intake, and a diet rich in fruits and vegetables, contributes to maintaining overall health ...
Roberto Mattioli, Daniel Di Risola, Carmen Chiaradia, Ivan Dimauro, Luciana Mosca, Guglielmo Duranti, Roberta Ceci   +6 more
wiley   +1 more source

Children and Young People With First Relapse or Progression of Upfront Metastatic Rhabdomyosarcoma: An Analysis of Clinical Features and Outcomes From the INternational Soft Tissue saRcoma ConsorTium (INSTRuCT)

Cancer Medicine, Volume 15, Issue 3, March 2026.
In this pooled analysis of 1095 patients with metastatic rhabdomyosarcoma, 3‐year overall survival was only 8% among the 727 patients with first event of relapse or progression. Patients “disease‐free” 3 years after first event had less locoregional lymph node involvement, fewer known adverse risk factors and lower Oberlin scores at first presentation ...
Ajla T. Wasti, Gianni Bisogno, Beatrice Coppadoro, Ilaria Zanetti, Martin Ebinger, Amadeus T. Heinz, Henry C. Mandeville, Rita Alaggio, Michela Casanova, Sheila E. J. Terwisscha van Scheltinga, Rick R. van Rijn, Veronique Minard‐Colin, Daniel Orbach, Natalie B. Collins, Wei Xue, Rajkumar Venkatramani, Johannes H. M. Merks, Julia C. Chisholm   +17 more
wiley   +1 more source

A Perspective on Polo-Like Kinase-1 Inhibition for the Treatment of Rhabdomyosarcomas

Frontiers in Oncology, 2019
Rhabdomyosarcomas are the most common pediatric soft tissue sarcoma and are a major cause of death from cancer in young patients requiring new treatment options to improve outcomes. High-risk patients include those with metastatic or relapsed disease and
Susanne A. Gatz, Susanne A. Gatz, Ewa Aladowicz, Michela Casanova, Julia C. Chisholm, Julia C. Chisholm, Pamela R. Kearns, Simone Fulda, Birgit Geoerger, Beat W. Schäfer, Janet M. Shipley   +10 more
doaj   +1 more source

Precision Oncology for Pediatric Solid Tumors Using In‐Hospital Pediatric/AYA Malignancy‐Specific Panel Sequencing

Cancer Science, Volume 117, Issue 3, Page 797-806, March 2026.
Our findings indicate that a pediatric/AYA‐specific targeted panel deployed in a hospital can deliver rapid, clinically actionable molecular insights with high diagnostic and prognostic yield. This complements larger sequencing platforms by offering speed, focused content, and easier interpretation.
Masato Kojima, Sho Kurihara, Isamu Saeki, Ryo Touge, Keigo Nakashima, Shuhei Karakawa, Fumiyuki Yamasaki, Satoshi Okada, Eiso Hiyama   +8 more
wiley   +1 more source

Alveolar rhabdomyosarcoma – The molecular drivers of PAX3/7-FOXO1-induced tumorigenesis

Skeletal Muscle, 2012
Rhabdomyosarcoma is a soft tissue sarcoma arising from cells of a mesenchymal or skeletal muscle lineage. Alveolar rhabdomyosarcoma (ARMS) is more aggressive than the more common embryonal (ERMS) subtype.
Marshall Amy D, Grosveld Gerard C
doaj   +1 more source