Results 71 to 80 of about 178 (122)

Entinostat as a combinatorial therapeutic for rhabdomyosarcoma

Scientific Reports
Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma. For the alveolar subtype (ARMS), the presence of the PAX3::FOXO1 fusion gene and/or metastases are strong predictors of poor outcome. Metastatic PAX3::FOXO1 + ARMS often responds to
Shefali Chauhan, Emily Lian, Iman Habib, Qianqian Liu, Nicole M. Anders, Megan M. Bugg, Noah C. Federman, Joel M. Reid, Clinton F. Stewart, Tristan Cates, Joel E. Michalek, Charles Keller   +11 more
doaj   +1 more source

Alveolar rhabdomyosarcoma: origin and prognostic implications of molecular findings

Boletín Médico del Hospital Infantil de México, 2016
We present the case of a 2-year-old male patient with a facial tumor partially treated with chemotherapy before his admission to our institution. The tumor involved from the frontal region to the maxillary floor, the orbit, and the maxillary and sphenoid
Pilar Eguía-Aguilar, Briceida López-Martínez, Carmen Retana-Contreras, Mario Perezpeña-Diazconti   +3 more
doaj   +1 more source

A Pax7::Foxo1 conditional mouse strain

Skeletal Muscle
Background The PAX7::FOXO1 subtype of alveolar rhabdomyosarcoma (aRMS) is both understudied and an unmet clinical need. The biology of PAX7::FOXO1 aRMS is significantly different than PAX3::FOXO1 aRMS, presenting an opportunity to gain biological ...
G. Roger Askew, Jonathan Gauntlett, Katherine Brechun, Harald Kranz, Nicholas Salters, Jess D. Tate, Ellen Wang, Cassie Badger, Shireen Elhabian, Jared Schnider, Gillian St. John, Samuel V. Rasmussen, Narendra Bharathy, Charles Keller   +13 more
doaj   +1 more source

Transcriptional Activation by Pax3‐FOXO1 is influenced by the presence of FOXO1 promoter elements

The FASEB Journal, 2012
The translocation of FOXO1 with either Pax3 or Pax 7 has been implicated in the development of Alveolar Rhabdomyosarcoma (ARMS). These translocations yield chimeric proteins containing amino‐terminal portions of either Pax transcription factor fused to carboxy terminal regions FOXO1.
Kelly E. Johanson, Endia L. Blunt, Chantelle L Collins, Elena Skripnikova   +3 more
openaire   +1 more source

Prognostic factors in patients with localized and metastatic alveolar rhabdomyosarcoma. A report from two studies and two registries of the Cooperative Weichteilsarkom Studiengruppe CWS

Cancer Medicine
Background The histologic classification of rhabdomyosarcoma (RMS) as alveolar (aRMS) or embryonal (eRMS) is of prognostic importance, with the aRMS being associated with a worse outcome.
Ewa Koscielniak, Sabine Stegmaier, Gustaf Ljungman, Bernarda Kazanowska, Felix Niggli, Ruth Ladenstein, Bernd Blank, Erika Hallmen, Christian Vokuhl, Claudia Blattmann, Monika Sparber‐Sauer, Thomas Klingebiel   +11 more
doaj   +1 more source

PAX3-FOXO1 Drives Targetable Cell State–Dependent Metabolic Vulnerabilities in Rhabdomyosarcoma

Cancer Research
Abstract PAX3-FOXO1, an oncogenic transcription factor, drives a particularly aggressive subtype of rhabdomyosarcoma (RMS) by enforcing gene expression programs that support malignant cell states.
Katrina I. Paras, Julia S. Brunner, Angela M. Montero, Jacob A. Boyer, Benjamin T. Jackson, Sangita Chakraborty, Abigail Xie, Kristina Guillan, Armaan Siddiquee, Lourdes Pajuelo Torres, Joshua D. Rabinowitz, Andrew L. Kung, Daoqi You, Filemon S. Dela Cruz, Lydia W.S. Finley   +14 more
openaire   +3 more sources

ESF-EMBO Symposium Molecular Biology and Innovative Therapies in Sarcomas of Childhood and AdolescenceSept 29 – Oct 4, Polonia Castle Pultusk, Poland

Frontiers in Oncology, 2013
Rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) are among the most common pediatric sarcomas (Arndt et al., 2012). Despite sarcomas representing a highly heterogeneous group of tumors, ES and alveolar RMS (ARMS) typically share one common genetic ...
Beat W Schäfer, Ewa eKoscielniak, Heinrich eKovar, Simone eFulda   +3 more
doaj   +1 more source

Preclinical rationale for entinostat in embryonal rhabdomyosarcoma

Skeletal Muscle, 2019
Background Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric cancer population. Survival among metastatic RMS patients has remained dismal yet unimproved for years.
Narendra Bharathy, Noah E. Berlow, Eric Wang, Jinu Abraham, Teagan P. Settelmeyer, Jody E. Hooper, Matthew N. Svalina, Zia Bajwa, Martin W. Goros, Brian S. Hernandez, Johannes E. Wolff, Ranadip Pal, Angela M. Davies, Arya Ashok, Darnell Bushby, Maria Mancini, Christopher Noakes, Neal C. Goodwin, Peter Ordentlich, James Keck, Douglas S. Hawkins, Erin R. Rudzinski, Atiya Mansoor, Theodore J. Perkins, Christopher R. Vakoc, Joel E. Michalek, Charles Keller   +26 more
doaj   +1 more source

Alveolar Paratesticular Rhabdomyosarcoma in an Adult Patient With PAX3-FOXO1 Fusion and Unfavorable Evolution

Cureus
Rhabdomyosarcomas, malignant mesenchymal tumors of skeletal striated muscle tissue cells, are usually rare in adults. However, when they occur in this population, the prognosis is usually poor, especially if the condition is associated with molecular factors such as the PAX3-FOXO1 fusion.
Paese, Eduardo O, Rodriguez, Rubens, Azambuja, Alan A   +2 more
openaire   +2 more sources

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source