Results 81 to 90 of about 20,380 (169)

DMRTA2 Regulates Radial Glial Maintenance and Tumorigenicity of Paediatric High‐Grade Glioma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT DMRTA2 is a member of the evolutionarily conserved transcription factor family involved in various developmental processes including neurogenesis. However, the roles of DMRTA2 in human development and disease are not fully characterised. Single cell RNA‐seq data analysis showed that DMRTA2 is robustly expressed in neural progenitors, in ...
Hitomi N. Royston, Autumn B. Hampton, Elissa G. Oliver, Jayden Jackson, Ibukunoluwa Tella, Miriam D. Emerson, Dhruv Bhagat, Grace E. Zimmerman, Daijiro Konno, Kosuke Funato   +9 more
wiley   +1 more source

Bilateral Eyelid Agenesis With Multiple Congenital Ocular Anomalies in an Australian Labradoodle Puppy: Case Report and Surgical Management

Veterinary Ophthalmology, Volume 29, Issue 2, March 2026.
ABSTRACT A 15‐week‐old Australian Labradoodle puppy was presented to The University of Queensland Small Animal Hospital for bilateral eyelid agenesis/coloboma and associated ocular complications. Enucleation of the left globe and repair of the right eyelid via a lip‐to‐lid transmucosal flap was performed. Given the subsequent development of prolapse of
Chi Hin Ng, Ticiana Brasil Ervedosa, José Granados Soler, Megan Elizabeth Climans, Viviana Gonzalez‐Astudillo   +4 more
wiley   +1 more source

Pax6 regulates neuronal migration and cell proliferation via interacting with Wnt3a during cortical development

Scientific Reports
The paired box 6 (Pax6) gene encodes a highly conserved transcription factor, involved in the development of eyes, brain, and endocrine glands. Homozygous loss of Pax6 resulted in neonatal death in mice, plus loss of eyes and malformation of cerebral ...
Bichao Zhang, Meihua Hou, Jiayan Huang, Yunfei Liu, Ciqing Yang, Juntang Lin   +5 more
doaj   +1 more source

PAX6 protein-protein interactions

, 2005
The gene PAX6 is located on chromosome 11 (1 lpl3) and encodes a transcription factor (PAX6) that is expressed early in development. The PAX6 protein is expressed in the developing eye, regions of the brain, central nervous system (CNS), nasal epithelium and pancreas.
openaire   +2 more sources

Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker.

PLoS ONE, 2015
The transcription factor Pax6 is an important regulator of development and cell differentiation in various organs. Thus, Pax6 was shown to promote neural development in the cerebral cortex and spinal cord, and to control pancreatic endocrine cell genesis.
Zeeshan Ahmad, Maria Rafeeq, Patrick Collombat, Ahmed Mansouri   +3 more
doaj   +1 more source

Increased corneal epithelial turnover contributes to abnormal homeostasis in the Pax6(+/-) mouse model of aniridia.

PLoS ONE, 2013
We aimed to test previous predictions that limbal epithelial stem cells (LESCs) are quantitatively deficient or qualitatively defective in Pax6(+/-) mice and decline with age in wild-type (WT) mice.
Panagiotis Douvaras, Richard L Mort, Dominic Edwards, Kanna Ramaesh, Baljean Dhillon, Steven D Morley, Robert E Hill, John D West   +7 more
doaj   +1 more source

A rare case of congenital aniridia with an unusual run-on mutation in PAX6 gene

Indian Journal of Ophthalmology, 2022
Ria Ratna, Shailja Tibrewal, Abha Gour, Reena Gupta, Umang Mathur, Vanita Vanita   +5 more
doaj   +1 more source

Take Pax6 for a Cortical 6-Pack

PLOS Biology, 2015
This synopsis examines the implications of a new study that imposes primate-like expression of the transcription factor Pax6 on the developing mouse cortex and finds evidence of primate-like proliferation of neuronal progenitors.
openaire   +4 more sources

Effect of retinoic acid treatment on the retinoic acid signaling pathway in a human siRNA-based aniridia limbal epithelial cell model, in vitro.

PLoS ONE
PurposeIn the present study, we evaluate gene and protein expression levels in an in vitro siRNA-mediated PAX6 knockdown limbal epithelial cell (LEC) model after RA treatment.
Shao-Lun Hsu, Tanja Stachon, Fabian N Fries, Zhen Li, Shuailin Li, Shanhe Liu, Berthold Seitz, Swarnali Kundu, Maryam Amini, Shweta Suiwal, Nóra Szentmáry   +10 more
doaj   +1 more source

Expression and clinical significance of PAX6 and miR-375-3p in ovarian endometriosis

徐州医科大学学报
Objective To investigate the expression and clinical significance of paired box gene 6 (PAX6) and microRNA-375-3p (miR-375-3p) in ovarian endometriosis (EMs).
WANG Simeng, WEI Min, LU Xiaoyuan, CHEN Buze, WANG Yijun   +4 more
doaj   +1 more source