Results 111 to 120 of about 6,419 (213)

A retrospective cohort study of Paxlovid efficacy depending on treatment time in hospitalized COVID-19 patients

open access: yeseLife
Paxlovid, a SARS-CoV-2 antiviral, not only prevents severe illness but also curtails viral shedding, lowering transmission risks from treated patients.
Zhanwei Du   +8 more
doaj   +1 more source

Paxlovid for the treatment of COVID-19: a systematic review and meta-analysis

open access: yesJournal of Infection in Developing Countries
Introduction: Paxlovid (nirmatrelvir/ritonavir) is a new oral antiviral drug that is used for coronavirus disease 2019 (COVID-19) and is administered to patients with mild to moderate disease for five consecutive days.
Yu Wang   +5 more
doaj   +1 more source

Prevention is better than healing. Clinical and economic implications of oral antiviral agents in COVID-19. A prospective study [PDF]

open access: yes
COVID-19 represents a threat for frailty patients. This study compares molnupiravir and nirmatrelvir for fragile COVID19 patients' efficacy, safety, and cost.
Cattaruzza, Maria Sofia   +6 more
core   +1 more source

Exploring The Inhibition of SARS-COV-2 PLpro: Docking and Molecular Dynamics Simulation of Flavonoid in Red Fruit Papua and Its Derivatives [PDF]

open access: yes
In early 2024, Covid-19 witnessed a substantial decline in cases. Nevertheless, with lingering cases and fatalities persisting, it remains crucial to focus on research to develop patented medicines to inhibit the spread of this virus effectively.
Ananto, Agus Dwi   +3 more
core   +2 more sources

Current Antiviral Options for Therapeutic Management Of SARS-CoV-2 Infection [PDF]

open access: yes
Introduction: The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent need for effective antiviral treatments.
Riego, Nyka Rane
core   +1 more source

Exploring early COVID-19 therapies, variants, and viral clearance dynamics: Insights from a high-risk outpatients study

open access: yes
This retrospective observational study investigates the impact of early COVID-19 therapies, including antivirals and monoclonal antibodies (mAbs), on time to achieve negative swab results in high-risk outpatients infected with specific Omicron ...
Bergna, Annalisa   +9 more
core   +2 more sources

LC-MS/MS Method Validation for Quantification of Nirmatrelvir in Human Plasma [PDF]

open access: yes
Nirmatrelvir, a key antiviral agent in the treatment of COVID-19, requires accurate and reliable monitoring of drug levels to optimize therapeutic efficacy.
Blessborn, Daniel   +2 more
core   +2 more sources

The problem of SARS-CoV-2 virus resistance to direct-acting antivirals

open access: yesБиопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. The high prevalence of mutations in the SARS-CoV-2 genome raises particular concerns about the resistance of the virus to current antiviral therapy, including inhibitors of the main protease, or 3C-like protease (3CLpro), and RNA-dependent ...
E. L. Gasich   +6 more
doaj   +1 more source

Paxlovid Awareness, Reporting Bias. [PDF]

open access: yesHealth affairs (Project Hope)
Widera, Eric, Lee, Todd C, Prasad, Vinay
openaire   +4 more sources

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