Results 81 to 90 of about 154,598 (309)

Expression of toll-like receptors (tlrs) in the equine peripheral blood mononuclear cells (pbmcs) during the early pregnancy and estrous cycle [PDF]

Eurasian Journal of Veterinary Sciences
Aim: Practical, reliable and economical pregnancy diagnosis method for as early as possible time of pregnancy in mares is still requirement. Immune tolerance against allogenic fetus is critically important during the early pregnancy.
Ercan Kurar, Mehmet Osman Atli, Aydin Guzeloglu, Seyit Ali Kayis, Ahmet Semacan   +4 more
doaj  

Repertoire analysis of memory T‐cell receptors in Japanese patients with inflammatory bowel disease

JGH Open, 2020
Background and Aim The T‐cell receptor (TCR) repertoire was assessed in response to various antigens and was considered to be associated with the pathogenesis of inflammatory bowel disease (IBD).
Yoichi Kakuta, Takeru Nakano, Takeo Naito, Kazuhiro Watanabe, Yasuhiro Izumiyama, Daisuke Okamoto, Ryo Ichikawa, Rintaro Moroi, Masatake Kuroha, Yoshitake Kanazawa, Tomoya Kimura, Hisashi Shiga, Takeshi Naitoh, Yoshitaka Kinouchi, Michiaki Unno, Atsushi Masamune   +15 more
doaj   +1 more source

ZIKV-susceptibility in subsets of human PBMCs.

, 2018
ZIKV-susceptibility in subsets of human PBMCs.
Lei Yu (70258), Ran Liu (303585), Min Li (12799), Lingzhai Zhao (5393258), Jin Sun (117866), Jianhua Wang (159545), Xia Jin (170912), Xin Wang (91924), Wenxin Hong (5393246), Fuchun Zhang (129371), Chao Zhang (51048)   +10 more
core   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

beta-Glucan Increases IFN-gamma and IL-12 Production of Peripheral Blood Mononuclear Cells with/without Induction of Mycobacterium tuberculosis Wild-type/Mutant DNA

Indonesian Biomedical Journal, 2019
BACKGROUND: In tuberculosis infections, the immune system is weakened and cannot produce enough cytokines to against the infection. b-glucan is a potent immunomodulator that induces cytokine production in various bacterial infections. This study aimed to
Meira Erawati, Nyoman Suci Widyastiti, Tri Indah Winarni, Edi Dharmana   +3 more
doaj   +1 more source

Perforin Secreting Cells from PBMCs.

, 2013
PBMCs were analyzed by ELISPOT as in Fig. 2, but in this case were stained for perforin production. A) Perforin secreting cells from individual animals. B) Mean perforin secreting cells from each group.
K. Jagannadha Sastry (221197), Patrick W. Hanley (429904), Philip Ng (265455), Michael A. Barry (226457), Bharti P. Nehete (429902), David C. Montefiori (108747), Guojun Yang (221194), Eric A. Weaver (226450), Stephanie J. Buchl (429903), Donna Palmer (265453), Guido Ferrari (164054), Pramod N. Nehete (221188)   +11 more
core   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Proliferation of PBMCs after stimulation.

, 2016
Bovine PBMCs were labeled with CFSE before stimulation with FTA alone, BVDV alone or BVDV plus FTA, and were assessed for their ability to proliferate at 72 (A)and 96 h (B) later by flow cytometry.
Wang Zhang (289732), Dong-Jie Cai (3115500), Xiao-Gang Weng (313565), Jiu-Feng Wang (313570), Quan-Jiang Song (3115503)   +4 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source