Results 111 to 120 of about 16,022 (277)

Characterizing Apixaban Pharmacokinetics Through Physiologically-Based Pharmacokinetic Modeling: Critical Role of Biliary Secretion and Enterohepatic Circulation in Humans. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Apixaban, a factor Xa inhibitor, is a direct oral anticoagulant with a well‐balanced elimination; it is eliminated evenly via feces, urine (with no active secretion), and as metabolites after oral administration. The common understanding is that biliary secretion and enterohepatic circulation (EHC) of apixaban are limited in humans, and that ...
Tsuchitani T, Kou W, Tomi M, Sugiyama Y.
europepmc   +2 more sources

Addressing human variability in next-generation human health risk assessments of environmental chemicals [PDF]

, 2012
International audienceCharacterizing variability in the extent and nature of responses to environmental exposures is a critical aspect of human health risk assessment.
Beal SL, Chiu WA, Dale Hattis, Frederic Y. Bois, Ivan Rusyn, Kathryn Z. Guyton, Lauren Zeise, Weihsueh A. Chiu   +7 more
core   +3 more sources

Physiologically Motivated Sequential Population Modeling of Albumin Trends and Vedolizumab Pharmacokinetics for Pregnancy Dosing Regimen Optimization

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 457-469, February 2026.
Physiologically Motivated Sequential Population Modeling of Albumin Trends and Vedolizumab Pharmacokinetics for Pregnancy Dosing Regimen Optimization. The pharmacokinetics (PK) of monoclonal antibodies (mAbs) during pregnancy remains poorly characterized, despite active inflammatory bowel diseases (IBD) being the greatest risk factor for adverse ...
Zrinka Duvnjak, Robin Michelet, Casper Steenholdt, Ella S.K. Widigson, Cæcilie Skejø, João A. Abrantes, Wilhelm Huisinga, Mette Julsgaard, Charlotte Kloft   +8 more
wiley   +1 more source

Development of a Pregnancy‐Specific Physiologically Based Pharmacokinetics (PBPK) Model for Aspirin

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Aspirin is one of the most commonly used medications in pregnancy, particularly for the prevention of hypertensive disorders. Despite aspirin's widespread use in pregnancy for preeclampsia prevention, its pharmacokinetics (PK) across all trimesters remain poorly characterized, complicating optimal dosing recommendations. To develop a pregnancy‐
Ana Collins‐Smith, Ananth Kumar Kammala, Mitch A. Phelps, Xiao Ming Wang, Ramkumar Menon, Maged M. Costantine   +5 more
wiley   +1 more source

A Tutorial on the Development of a Physiologically Inspired PKRO Model for Monoclonal Antibodies

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Modeling and simulations are indispensable tools to describe pharmacokinetics (PK) and pharmacodynamics to support monoclonal antibody (mAb) development. The linear PK of mAbs is commonly described by a 2‐compartment PK model, while the nonlinear PK often observed at low doses is described by target mediated drug disposition (TMDD) models ...
Georgi I. Kapitanov, David Flowers, Diana H. Marcantonio, Timothy R. Lezon, Josh F. Apgar, Fei Hua   +5 more
wiley   +1 more source

A Generalized Minimal PBPK‐PD Model of Bispecific Antibodies: Case Studies and Applications in Drug Development

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Bispecific antibodies (bsAbs), for which each arm binds a distinct molecular target, are developed to engage soluble and cell surface targets in different therapeutic indications. Three key examples of mechanisms of action (MoA) for bsAbs are (1) immune cell engagers that foster immune cell interactions with target cells, (2) bispecifics that ...
Phillip Spinosa, Louis Joslyn, Saroja Ramanujan, Kapil Gadkar, Iraj Hosseini   +4 more
wiley   +1 more source

Alcohol intoxication progressively impairs drivers' capacity to detect important environmental stimuli [PDF]

, 2018
Rationale Alcohol intoxication impairs driving skills, leading to an increased frequency of accidents and crash fatalities. Inebriation may specifically impair environmental vigilance, reducing the driver's capacity for attention to stimuli that are ...
Justiss, Michael D., Koskie, Sarah, Kosobud, Ann, O'Connor, Sean, Plawecki, Martin Henry   +4 more
core   +1 more source

Beyond the Michaelis–Menten: Evaluation of a tQSSA‐Based IVIVE Approach for Predicting In Vivo Intrinsic Clearance From Hepatocyte Assays

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT The classical Michaelis–Menten model, under the standard quasi‐steady‐state approximation (sQSSA), is widely used in in vitro‐in vivo extrapolation (IVIVE) studies using hepatocyte or human liver microsomal (HLM) assays to predict intrinsic hepatic clearance (Clint,vitro$$ {\mathrm{Cl}}_{\operatorname{int},\mathrm{vitro}} $$).
Ngoc‐Anh Thi Vu, Yun Min Song, Sang Kyum Kim, Hwi‐yeol Yun, Soyoung Lee, Jae Kyoung Kim, Jung‐woo Chae   +6 more
wiley   +1 more source

Prediction of Pharmacokinetic Drug–Drug Interactions Involving Anlotinib as a Victim by Using Physiologically Based Pharmacokinetic Modeling

Drug Design, Development and Therapy
Fengjiao Bu,1,2,* Yong-Soon Cho,3,4,* Qingfeng He,1 Xiaowen Wang,1 Saurav Howlader,3,4 Dong-Hyun Kim,3,4 Mingshe Zhu,5 Jae Gook Shin,3,4 Xiaoqiang Xiang1,6 1Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan ...
Bu F, Cho YS, He Q, Wang X, Howlader S, Kim DH, Zhu M, Shin JG, Xiang X   +8 more
doaj  

Pharmacokinetic-Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance. [PDF]

, 2018
Pharmacokinetic/pharmacodynamic (PKPD) modeling is important in the design and conduct of clinical pharmacology research in children. During drug development, PKPD modeling and simulation should underpin rational trial design and facilitate extrapolation
A Cram, A Hooker, A Rao, AA Vinks, AH Thomson, AK Done, AM Johansson, AN Edginton, AN Edginton, AR Maharaj, AR Maharaj, B Green, B Quijano Ruiz, BJ Anderson, BJ Anderson, C Stockmann, CA Knibbe, CC Peck, CF Weiss, Charlotte I. S. Barker, CI Barker, CIS Barker, D Lin, DB Hawcutt, DJ Eleveld, E Germovsek, E Germovsek, E Germovsek, E Kimland, E Manolis, E Manolis, EI Ette, EI Ette, Eva Germovsek, F Rodieux, FG Benedict, G Langdon, G Nellis, GEP Box, GJ Robbie, GL Kearns, H Kimko, H Mulla, H Padari, H Shirkey, HG Eichler, HM Jones, HS Al-Sallami, I Adatia, I Bains, I Mahmood, I Mahmood, I Mahmood, IH Bartelink, J Alcorn, J Dunne, J Gillis, J Lerman, J Nyberg, J Nyberg, JA Roberts, JD Crawford, JE Sager, JF Standing, JF Standing, JF Standing, JK Roberts, JM Nicolas, Joseph F. Standing, JR Bellis, JS Barrett, JS Barrett, JS Barrett, JT Gilman, K Kipper, KD Wittmeier, KL Brouwer, L Aarons, L Cuzzolin, L Harnisch, L Harnisch, LE Kelly, LV Hampson, M Cella, M Cella, M Cella, M Danhof, M Jamei, M Kleiber, M Kleiber, M Minocha, M Neely, M Pfister, M Rowland, MA Montenegro, MA Turner, MA Turner, MA Turner, MA Turner, Mike Sharland, ML Christensen, MM Rhodin, MO Karlsson, MY Peeters, N Holford, N Kleiber, N Modi, NH Holford, P Espie, PA Valitalo, PD Joseph, PH Graaf van der, RE Kauffman, RF Cock De, RM Ward, RM Ward, RS Kadam, RW Jelliffe, S Conroy, S Duffull, S Feng, S Hennig, S Hennig, S Kanoh, S Leroux, SC McLeay, SE Tett, SG Wicha, SM MacLeod, SW Briggs, T Schechter, TA Leil, TA Leil, TH Nguyen, TN Johnson, TN Johnson, TN Johnson, TP Klassen, TS Samant, V Ramos-Martin, VH Tam, W Knebel, W Van’t Hoff, W Zhao, WA Silverman, Y Wang   +145 more
core   +2 more sources