Results 131 to 140 of about 5,951 (176)

Physiologically based pharmacokinetics (PBPK)

Drug Metabolism Reviews, 2009
Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical species, and many different approaches have been proposed over the years to improve its predictive performance. Nevertheless, prediction errors are commonly observed in the practical application of simple allometry, for example, in cases where the hepatic ...
Pascal, Espié, Dominique, Tytgat, Maria-Laura, Sargentini-Maier, Italo, Poggesi, Jean-Baptiste, Watelet   +4 more
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PHYSIOLOGICAL “CONSTANTS” FOR PBPK MODELS FOR PREGNANCY

Journal of Toxicology and Environmental Health, 1997
Physiologically based pharmacokinetic (PBPK) models for pregnancy are inherently more complex than conventional PBPK models due to the growth of the maternal and embryo/fetal tissues. Physiological parameters such as compartmental volumes or flow rates are relatively constant at any particular time during gestation when an acute experiment might be ...
J F, Young, W S, Branham, D M, Sheehan, M E, Baker, W D, Wosilait, R H, Luecke   +5 more
openaire   +2 more sources

Postnatal Growth Considerations for PBPK Modeling

Journal of Toxicology and Environmental Health, Part A, 2007
A physiologically based pharmacokinetic (PBPK) model and Windows-based program (called PostNatal) was developed that focuses on postnatal growth, from birth through adulthood, using appropriate growth curves for each species and gender. Postnatal growth algorithms relating organs/tissues weights with total body weight for male and female humans, dogs ...
Richard H, Luecke, Bruce A, Pearce, Walter D, Wosilait, William, Slikker, John F, Young   +4 more
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PBPK and Toxicokinetic Modeling

2022
Presentation to OpenTox 2022 on Sept. 16, 2022 Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=& ...
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Development of a PBPK Model for Monoclonal Antibodies and Simulation of Human and Mice PBPK of a Radiolabelled Monoclonal Antibody

Current Pharmaceutical Design, 2009
Physiology based pharmacokinetic (PBPK) modeling and simulation is a useful method for prediction of biodistribution of both macromolecules and small molecules. It can enhance our understanding of the underlying mechanisms of biodistribution and hence may help in rational design of macromolecules used as diagnostic and therapeutic agents.
Tomi, Heiskanen, Tomas, Heiskanen, Kalevi, Kairemo   +2 more
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Analysis of PBPK Models for Risk Characterization

Annals of the New York Academy of Sciences, 1999
Abstract: Adoption of a Bayesian framework for risk characterization permits the seamless integration of different kinds of information available in order to choose and parameterize risk models. It also becomes easy to disentangle uncertainty from variability, through hierarchical statistical modeling.
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PBPK modeling of irbesartan: incorporation of hepatic uptake

Biopharmaceutics & Drug Disposition, 2015
AbstractPhysiological based pharmacokinetic (PBPK) modeling is now commonly used in drug development to integrate human or animal physiological data in order to predict pharmacokinetic profiles. The aim of this work was to construct and refine a PBPK model of irbesartan taking into account its active uptake via OATP1B1/B3 in order to predict more ...
Chapy, Hélène, Klieber, Sylvie, Brun, Priscilla, Gerbal-Chaloin, Sabine, Boulenc, Xavier, Nicolas, Olivier   +5 more
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A PBPK model for midazolam in four avian species

Journal of Veterinary Pharmacology and Therapeutics, 2009
A physiologically based pharmacokinetic (PBPK) model was developed for midazolam in the chicken and extended to three other species. Physiological parameters included organ weights obtained from 10 birds of each species and blood flows obtained from the literature. Partition coefficients for midazolam in tissues vs.
K A, Cortright, S E, Wetzlich, A L, Craigmill   +2 more
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PBPK modeling of complex hydrocarbon mixtures: gasoline

Environmental Toxicology and Pharmacology, 2004
Petroleum hydrocarbon mixtures such as gasoline, diesel fuel, aviation fuel, and asphalt liquids typically contain hundreds of compounds. These compounds include aliphatic and aromatic hydrocarbons within a specific molecular weight range and sometimes lesser amounts of additives, and often exhibit qualitatively similar pharmacokinetic (PK) and ...
James E, Dennison, Melvin E, Andersen, Ivan D, Dobrev, Moiz M, Mumtaz, Raymond S H, Yang   +4 more
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Physiologically Based Pharmacokinetic (PBPK) Modeling in Children

Clinical Pharmacology & Therapeutics, 2012
This review summarizes the present status of physiologically based pharmacokinetic (PBPK) modeling and simulation (M&S) and its application in support of pediatric drug research. We address the reasons that PBPK is suited to the current needs of pediatric drug development and pharmacotherapy in light of the evolution in pediatric PBPK methodologies and
J S, Barrett, O, Della Casa Alberighi, S, Läer, B, Meibohm   +3 more
openaire   +2 more sources