Results 141 to 150 of about 11,787 (237)

Suzetrigine Is Not Expected to Have Clinically Relevant DDIs with Apixaban and Rivaroxaban Based on PBPK Modeling. [PDF]

J Clin Pharmacol
Wang G, Lakota E, Feng B, Jiang L, Liang G, Hare B.   +5 more
europepmc   +1 more source

Human PBPK Modeling

This deliverable will report the final development of the human PBPK models developed within ...
openaire   +1 more source

Integrating CRRT as a Virtual Organ Into Physiologically Based Pharmacokinetic Modeling to Optimize Antimicrobial Dosing in Septic Patients. [PDF]

CPT Pharmacometrics Syst Pharmacol
Xing Y, Zhang Y, Bai C, Qiu Y, Wang C, Chen L, Wang T, Chen J.   +7 more
europepmc   +1 more source

Transitioning from Transcriptomics to Proteomics: Enhancing Mechanistic Accuracy in PBPK Modeling via Absolute Protein Abundances. [PDF]

CPT Pharmacometrics Syst Pharmacol
Ning C, Pugliano A, Winter M, Wu K, Annaert P.   +4 more
europepmc   +1 more source

A hybrid ML-PBPK digital twin framework for clinically interpretable readmission risk and drug exposure stratification in diabetes. [PDF]

Front Digit Health
Ahmed K N, Ibrahim Syed Masood JA.
europepmc   +1 more source

Issue Information

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
wiley   +1 more source

Transporter-Drive Interstitial Tissue Exposure and Pharmacodynamic Response of Meropenem in Sepsis: A Mechanistic PBPK Modeling Study. [PDF]

CPT Pharmacometrics Syst Pharmacol
Olivo LB, de Lemos JLS, Rodrigues VJ, de Araújo BV.   +3 more
europepmc   +1 more source

A PBPK-VBE approach for bioequivalence extrapolation of senaparib capsule strengths in the context of nonlinear pharmacokinetics: bridging from the clinical starting dose to the linear pharmacokinetic range. [PDF]

Front Pharmacol
Wu X, Wang Z, He Y, Wu K, Liu B, Ma N, Cai S, Xu C, Xu Y, Zhao S, Wang H.   +10 more
europepmc   +1 more source

Predicting First-in-Human Pharmacokinetics: Comparative Evaluation of Standard PBPK, High-Throughput PBPK, and Machine Learning. [PDF]

Mol Pharm
Käser S, Bassani D, Parrott NJ, Umehara K, Delporte ML, David-Pierson P.   +5 more
europepmc   +1 more source

Integration of microphysiological systems with computational and digital twin modeling for pharmaceutical development: a systematic review. [PDF]

J Pharm Pharm Sci
Soheili M, Gilzad Kohan B, Rastegar L, Moradi Y, Gilzad Kohan H.   +4 more
europepmc   +1 more source