Results 141 to 150 of about 9,895 (222)

Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic cornerstone of model‐informed drug development (MIDD), providing evidence for regulatory decisions. PBPK models integrate physiological and pharmacological data and have been applied across a plethora of contexts of use, including assessing drug–drug interactions (DDIs ...
Marylore Chenel, Andre Dallmann, Ibrahim Ince, Michaela Meyer, Jan‐Frederik Schlender, Donato Teutonico, Erik Sjögren   +6 more
wiley   +1 more source

Développement et évaluation d'un modèle de PBPK Murin appliqué en cancérologie [PDF]

, 2012
La modélisation pharmacocinétique est une discipline qui se développe depuis de nombreuses années. De nouvelles techniques de modélisation telle que la PBPK permettent de prédire de manière physiologique la cinétique de molécules actives chez différentes
FAURE, Sébastien, VIGUERIE, Laure
core  

PBPK Modeling and Clinical Data Reveal Reduced Impact of CYP3A4 and CYP2C9 Inhibitors on Elimination of Siponimod

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
ABSTRACT Multiple sclerosis (MS) is a significant cause of neurological disability in young adults. Siponimod, a potent sphingosine‐1‐phosphate (S1P) receptor modulator, is used to treat MS by reducing T‐cell recirculation and central inflammation. The presented work includes clinical data describing the impact of the CYP3A4 inhibitor clarithromycin on
Felix Huth, Kasra Shakeri‐Nejad, Anne Gardin, Bharti Shah, Oliver Pohl, Nicole Pezous, Thomas Faller   +6 more
wiley   +1 more source

Optimizing Venous Thromboembolism Prophylaxis in Burn Patients Using Enoxaparin Through PBPK Modeling. [PDF]

CPT Pharmacometrics Syst Pharmacol
Mim SR, Yellepeddi VK, Azeredo FJ.
europepmc   +1 more source

Physiologically Based Pharmacokinetic Model to Predict Drug-Drug Interactions With the Antibody-Drug Conjugate Trastuzumab Deruxtecan. [PDF]

CPT Pharmacometrics Syst Pharmacol
Watanabe A, Gill KL, Chen KF, Jones HM, De Sousa Mendes M, Gardner I, Kotsuma M.   +6 more
europepmc   +1 more source

Age-Driven Physiologically Based Pharmacokinetic Modeling of Empagliflozin: Toward Precision Dosing in Youth. [PDF]

ACS Pharmacol Transl Sci
Milhm GP, Moreira FL, Abrahim-Vieira BA.
europepmc   +1 more source

Human PBPK Modeling

This deliverable will report the final development of the human PBPK models developed within ...
openaire   +1 more source

Physiologically Based Pharmacokinetic-Pharmacodynamic-Based Quantification of Exposure-Response for Sodium Tanshinone IIA Sulfonate in Normal and Cerebral Ischemia-Reperfusion Injury Rats. [PDF]

Biology (Basel)
Chen Y, Zhang J, Zhang Y, Qin T, Jin W, Wang Y, Chen Y, Yu L, Zhang L.   +8 more
europepmc   +1 more source

Physiologically Based Pharmacokinetic Modeling of Elexacaftor/Tezacaftor/Ivacaftor in Infants With Cystic Fibrosis. [PDF]

CPT Pharmacometrics Syst Pharmacol
Truong NH, Benaboud S, Bouazza N, Deneuville E, Mornand A, Reix P, Ribault M, Burgel PR, Froelicher-Bournaud L, Rouillon S, Sanoufi MR, Lui G, Urien S, Tréluyer JM, Sermet-Gaudelus I, Foissac F, Modul‐CF study group.   +16 more
europepmc   +1 more source

Model-informed dose optimization of carvedilol and nebivolol in cirrhotic patients: a pilot randomized clinical study. [PDF]

Sci Rep
Tarek M, Ali AA, Biomy R, Abdelkawy K, El-Khateeb E.   +4 more
europepmc   +1 more source