Exploring Tafamidis Effects Through PBPK-QSP Modelling. [PDF]
PharmaceuticsUlaszek S +3 more
europepmc +1 more source
From Population-Based PBPK to Individualized Virtual Twins: Clinical Validation and Applications in Medicine. [PDF]
J Clin MedGonçalves M, Barata P, Vale N.
europepmc +1 more source
Utility of a physiologically-based pharmacokinetic model for investigating time-dependent variability in the fetal-to-maternal plasma concentration ratio of digoxin. [PDF]
J Pharmacokinet PharmacodynOkuba K, Ikeda K.
europepmc +1 more source
Comprehensive Pathophysiology Repository for PBPK Modeling in Liver Cirrhosis: Quantifying Continuous Disease Progression and Population Variability. [PDF]
CPT Pharmacometrics Syst PharmacolSchneider ARP +3 more
europepmc +1 more source
Addressing Adherence Using Genotype-Specific PBPK Modeling—Impact of Drug Holidays on Tamoxifen and Endoxifen Plasma Levels [PDF]
, 2017 Georg Hempel +3 more
core +1 more source
Physiologically-Based Pharmacokinetics of Ribociclib Drug-Drug Interactions and Organ Impairment Pharmacokinetics in Early Breast Cancer. [PDF]
Pharmaceuticals (Basel)Ji Y +8 more
europepmc +1 more source
Quantitative systems toxicology approach that integrates PBPK and core hepatic metabolism: a case study with valproic acid. [PDF]
Front PharmacolGupta V, Jo H, Fisher CP, Kierzek AM.
europepmc +1 more source
Modellierung PBPK-relevanter Verteilungskoeffizienten organischer Stoffe
, 2014 Drei Verteilungskoeffizienten, die für physiologie-basierte Pharmakokinetik (PBPK)-Modelle relevant sind, wurden mit verschiedenen Ansätzen modelliert. Für den Blut/Luft-Verteilungskoeffizienten wurde ein auf linearen Solvatations-Energie-Beziehungen (LSER) beruhendes Literaturmodell angewendet und diskutiert.
openaire +1 more source
PBPK modeling of the antidepressant doxepin incorporating CYP2D6 genotype for precision pharmacotherapy. [PDF]
Arch Pharm ResSeok J, Kang N, Lee JJ, Cho CK, Lee YJ.
europepmc +1 more source