Results 171 to 180 of about 11,787 (237)

Model-Informed Drug Development (MIDD) for Analgesics: Review of Applications, Regulatory Integration, and Emerging Directions. [PDF]

J Pain Res
Dahan A, Pergolizzi JV, Niesters M, Olofsen E, Raffa RB.   +4 more
europepmc   +1 more source

PBPK-Based Prediction of Oliceridine Exposure in Breast Milk and Relative Infant Dose During the First 24 h After Cesarean Delivery. [PDF]

J Clin Pharmacol
Ding Y, Liu K, Zhang S, Zhang Y, Tan X, Xu W.   +5 more
europepmc   +1 more source

Application of Physiologically Based Pharmacokinetic Modeling to Optimize Assessment of Age-Related Fluoxetine Accumulation in the Elderly. [PDF]

CPT Pharmacometrics Syst Pharmacol
Jang YJ, Heo DG, Hong E.
europepmc   +1 more source

A multiscale PBPK-PD model of oxytocin-induced uterine excitation and contraction. [PDF]

J Physiol
Yang Y, Bradley C, Zhang X, Clark A, Gao M, Li G, Yang L, Monfort-Ortiz R, Meng Y, Hao D, Ye-Lin Y.   +10 more
europepmc   +1 more source

Development and Evaluation of Physiologically Based Pharmacokinetic (PBPK) Models to Investigate the Effect of CYP2D6 Polymorphism on Metoclopramide Systemic Exposure. [PDF]

Pharmaceuticals (Basel)
Shahzad I, Zamir A, Rasool MF, Alali AS, Hussain I, Alqahtani F.   +5 more
europepmc   +1 more source

Physiologically based pharmacokinetic model of two ALK inhibitors to inform drug and dosing regimens for brain metastasis patients. [PDF]

Front Pharmacol
Yao N, Liu J, Xue Q, Liu J.
europepmc   +1 more source

PK-Informed Microphysiological Systems: From Dynamic Dosing to Quantitative In Vitro-In Vivo Translation. [PDF]

Pharmaceutics
Kang SJ, Bong S, Jo MJ, Lee JM, Yoon MS, Park S, Lee Y, Shin Y, Lee HJ, Park CW, Shin DH.   +10 more
europepmc   +1 more source

Coproporphyrin I PBPK model in the open systems pharmacology suite enables precise prediction of OATP 1B- mediated drug interactions through calibrated <i>In vivo</i> inhibition constants. [PDF]

Front Pharmacol
Kanacher T, Pellowe M, Kovar C, Eriksson J, Wu J, Busse D, Gómez-Mantilla JD, Stopfer P, Ince I, Huang F.   +9 more
europepmc   +1 more source

Physiologically Based Pharmacokinetic Modeling of Vedolizumab in Healthy Adults and Patients with Inflammatory Bowel Disease. [PDF]

Clin Pharmacokinet
Parikh S, Irie K, Tanaka R, Nadai T, Minar P, Mizuno T.   +5 more
europepmc   +1 more source