Results 191 to 200 of about 14,687 (252)

Development of a Physiologically Based Pharmacokinetic (PBPK) Simulation Model for Nicotine. [PDF]

Biopharm Drug Dispos
Kim B, Bae SH, Bashar M, Yi B, Rahman MA, Awuah P, Hartog M, Panarsky R, Zhang T.   +8 more
europepmc   +1 more source

Predicting drug-drug interactions between ayahuasca alkaloids and SSRIs using physiologically based pharmacokinetic modeling. [PDF]

Front Mol Biosci
Ribeiro GSG, Paranhos BAPB, Dörr F, Yonamine M, Villanova B, Guerra LTL, Raminelli AO, Reis JAS, de Paula CC, Zacharias ABV, Cecílio Hallak JE, Dos Santos RG, Martins FS, Marcourakis T.   +13 more
europepmc   +1 more source

Strategy for Identifying Rational Sensitivity Analysis Using PBPK Modeling for Precipitant Drug-Drug Interaction Predictions. [PDF]

Clin Pharmacol Ther
Taskar KS, Sharma P, Rowland Yeo K.
europepmc   +1 more source

Mechanistic mathematical modeling of abscopal effect reveals mechanisms of off-target tumor response. [PDF]

Front Immunol
Hadjigeorgiou AG, Roussakis Y, Zamboglou C, Stylianopoulos T.   +3 more
europepmc   +1 more source

Mechanism-Based Predictions of Local Tissue and Systemic Exposure for Drug Products Delivered Through the Female Reproductive Tract. [PDF]

J Clin Pharmacol
Li X, Straubinger T, Rohan LC, Achilles SL, Chen BA, Valicherla G, Zhang Z, Donnelly M, Tsakalozou E, Zhao L, Bies R.   +10 more
europepmc   +1 more source

PBPK in liver cirrhosis population

, 2019
openaire   +1 more source

Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model [PDF]

CPT: Pharmacometrics and Systems Pharmacology, 2016
The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled ...
Kuepfer, L, Niederalt, C, Wendl, T, Schlender, J‐F, Willmann, S, Lippert, J, Block, M, Eissing, T, Teutonico, D   +8 more
exaly   +3 more sources

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Physiologically based pharmacokinetics (PBPK)

Drug Metabolism Reviews, 2009
Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical species, and many different approaches have been proposed over the years to improve its predictive performance. Nevertheless, prediction errors are commonly observed in the practical application of simple allometry, for example, in cases where the hepatic ...
Pascal, Espié, Dominique, Tytgat, Maria-Laura, Sargentini-Maier, Italo, Poggesi, Jean-Baptiste, Watelet   +4 more
openaire   +2 more sources