Results 201 to 210 of about 14,687 (252)
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Postnatal Growth Considerations for PBPK Modeling
Journal of Toxicology and Environmental Health, Part A, 2007A physiologically based pharmacokinetic (PBPK) model and Windows-based program (called PostNatal) was developed that focuses on postnatal growth, from birth through adulthood, using appropriate growth curves for each species and gender. Postnatal growth algorithms relating organs/tissues weights with total body weight for male and female humans, dogs ...
Richard H, Luecke +4 more
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PBPK and Toxicokinetic Modeling
2022Presentation to OpenTox 2022 on Sept. 16, 2022 Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=& ...
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PHYSIOLOGICAL “CONSTANTS” FOR PBPK MODELS FOR PREGNANCY
Journal of Toxicology and Environmental Health, 1997Physiologically based pharmacokinetic (PBPK) models for pregnancy are inherently more complex than conventional PBPK models due to the growth of the maternal and embryo/fetal tissues. Physiological parameters such as compartmental volumes or flow rates are relatively constant at any particular time during gestation when an acute experiment might be ...
J F, Young +5 more
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Modelling and PBPK Simulation in Drug Discovery [PDF]
AAPS Journal, 2009 Physiologically based pharmacokinetic (PBPK) models are composed of a series of differential equations and have been implemented in a number of commercial software packages. These models require species-specific and compound-specific input parameters and allow for the prediction of plasma and tissue concentration time profiles after intravenous and ...
Hannah M, Jones +2 more
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Physiologically Based Pharmacokinetic (PBPK) Modeling of Pharmaceutical Nanoparticles
AAPS Journal, 2016With the great interests in the discovery and development of drug products containing nanoparticles, there is a great demand of quantitative tools for assessing quality, safety, and efficacy of these products. Physiologically based pharmacokinetic (PBPK) modeling and simulation approaches provide excellent tools for describing and predicting in vivo ...
Peng Zou
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Analysis of PBPK Models for Risk Characterization
Annals of the New York Academy of Sciences, 1999Abstract: Adoption of a Bayesian framework for risk characterization permits the seamless integration of different kinds of information available in order to choose and parameterize risk models. It also becomes easy to disentangle uncertainty from variability, through hierarchical statistical modeling.
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QSARs for PBPK modelling of environmental contaminants
SAR and QSAR in Environmental Research, 2011Physiologically-based pharmacokinetic (PBPK) models are increasingly finding use in risk assessment applications of data-rich compounds. However, it is a challenge to determine the chemical-specific parameters for these models, particularly in time- and resource-limiting situations.
T, Peyret, K, Krishnan
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Windows based general PBPK/PD modeling software
Computers in Biology and Medicine, 2008A physiologically based pharmacokinetic (PBPK) model and program (called PostNatal) was developed which focuses on postnatal growth. Algorithms defining organ/tissue growth curves from birth through adulthood for male and female humans, dogs, rats, and mice are utilized to calculate the appropriate weight and blood flow for the internal organs/tissues.
Richard H, Luecke +5 more
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PBPK modeling of complex hydrocarbon mixtures: gasoline
Environmental Toxicology and Pharmacology, 2004Petroleum hydrocarbon mixtures such as gasoline, diesel fuel, aviation fuel, and asphalt liquids typically contain hundreds of compounds. These compounds include aliphatic and aromatic hydrocarbons within a specific molecular weight range and sometimes lesser amounts of additives, and often exhibit qualitatively similar pharmacokinetic (PK) and ...
James E, Dennison +4 more
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