Results 181 to 190 of about 11,787 (237)
Physiologically based pharmacokinetic modeling of fluconazole: interpretation of gender-dependent pharmacokinetics and cytochrome P450 inhibition. [PDF]
Front PharmacolIshida K, Tanna RS, Yang J, Lai Y.
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Physiologically based pharmacokinetic modeling of cefotaxime to inform pediatric dosing in renal impairment. [PDF]
Eur J Clin PharmacolRahim N, Sarfraz M, Wahajuddin M.
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From bench to bedside: Overcoming translational hurdles in nanoparticle research with pharmacokinetic modeling. [PDF]
Bioeng Transl MedParrot M +6 more
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PBPK modeling and simulation in drug research and development [PDF]
Acta Pharmaceutica Sinica B, 2016 Physiologically based pharmacokinetic (PBPK) modeling and simulation can be used to predict the pharmacokinetic behavior of drugs in humans using preclinical data.
Xiaomei Zhuang, Chuang Lu
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PBPK model reporting template for chemical risk assessment applications
Regulatory Toxicology and Pharmacology, 2020 Physiologically-based pharmacokinetic (PBPK) modeling analysis does not stand on its own for regulatory purposes but is a robust tool to support drug/chemical safety assessment.
Michelle Embry +2 more
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Modelling and PBPK Simulation in Drug Discovery [PDF]
AAPS Journal, 2009 Physiologically based pharmacokinetic (PBPK) models are composed of a series of differential equations and have been implemented in a number of commercial software packages. These models require species-specific and compound-specific input parameters and allow for the prediction of plasma and tissue concentration time profiles after intravenous and ...
Hannah Jones
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Nanomaterials, 2020 There have been efforts to develop physiologically based pharmacokinetic (PBPK) models for nanomaterials (NMs). Since NMs have quite different kinetic behaviors, the applicability of the approaches and techniques that are utilized in current PBPK models ...
Wells Utembe +2 more
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PHYSIOLOGICAL “CONSTANTS” FOR PBPK MODELS FOR PREGNANCY
Journal of Toxicology and Environmental Health, 1997Physiologically based pharmacokinetic (PBPK) models for pregnancy are inherently more complex than conventional PBPK models due to the growth of the maternal and embryo/fetal tissues. Physiological parameters such as compartmental volumes or flow rates are relatively constant at any particular time during gestation when an acute experiment might be ...
J F, Young +5 more
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