Results 211 to 220 of about 14,363 (238)
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PBPK Modeling Advances Understanding of D4 Pharmacokinetics
Toxicological Sciences, 2003The article highlighted in this issue is Physiological Modeling of Inhalation Kinetics of Octamethylcyclotetrasiloxane in Humans during Rest and Exercise, by Micaela B. Reddy, Melvin E. Andersen, Paul E. Morrow, Ivan D. Dobrev, Sudarsanan Varaprath, Kathleen P. Plotzke, and Mark J. Utell (pp. 43-56).
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PBPK modeling of irbesartan: incorporation of hepatic uptake
Biopharmaceutics & Drug Disposition, 2015AbstractPhysiological based pharmacokinetic (PBPK) modeling is now commonly used in drug development to integrate human or animal physiological data in order to predict pharmacokinetic profiles. The aim of this work was to construct and refine a PBPK model of irbesartan taking into account its active uptake via OATP1B1/B3 in order to predict more ...
Helene, Chapy +5 more
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Physiologically Based Pharmacokinetic (PBPK) Modeling of Pharmaceutical Nanoparticles
The AAPS Journal, 2016With the great interests in the discovery and development of drug products containing nanoparticles, there is a great demand of quantitative tools for assessing quality, safety, and efficacy of these products. Physiologically based pharmacokinetic (PBPK) modeling and simulation approaches provide excellent tools for describing and predicting in vivo ...
Min, Li +3 more
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PBPK in Preterm and Term Neonates: A Review
Current Pharmaceutical Design, 2018The neonatal population remains one of the populations in which appropriate dosing regimens are still lacking, resulting in a large off-label or unlicensed use. Clinical research in these small infants remains a challenge, which sparks the need for modeling and simulation as an additional tool for neonatal drug research.The use of physiologically based
Robin, Michelet +2 more
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Sensitivity Analysis- Theory and PBPK Applications
2021Presentation to the OECD, Paris (Virtual Meeting Test on April 30th, 2021 - Final presentation on May 10, 2021)Search for CCTE records in EPA s Science Inventory by typing in the title at this link.https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber ...
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A PBPK model for midazolam in four avian species
Journal of Veterinary Pharmacology and Therapeutics, 2009A physiologically based pharmacokinetic (PBPK) model was developed for midazolam in the chicken and extended to three other species. Physiological parameters included organ weights obtained from 10 birds of each species and blood flows obtained from the literature. Partition coefficients for midazolam in tissues vs.
K A, Cortright +2 more
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Assessing interindividual variability by Bayesian-PBPK modeling
Drug Discovery Today: Disease Models, 2016The description of interindividual variability and the ADME-related sources of such variability (ADME: absorption, distribution, metabolization, excretion) is an essential element in clinical drug development to identify potentially relevant subgroups of non-responders or high-risk patients.
Markus Krauss, Andreas Schuppert
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