Results 41 to 50 of about 16,022 (277)

Physiologically based modeling and prediction of drug interactions [PDF]

, 2010
International audienceA major challenge for drug development and environmental or occupational health is the prediction of pharmacokinetic and pharmacodynamic interactions between drugs, natural chemicals or environmental contaminants.
Bois, Frédéric Y.
core   +3 more sources

Comparison of Metformin PBPK Models Incorporating Placental Transfer to Predict Fetal and Maternal Exposure. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling of placental drug transfer is an evolving tool for predicting fetal drug exposure. In this study, a pregnancy‐specific metformin PBPK model was developed, and the following four approaches were evaluated to predict metformin placental transfer: (1) perfusion‐limited model, and permeability ...
Tiley JB, Hartauer ME, Whigham TL, Mendes MS, Brouwer KLR, Hebert MF.   +5 more
europepmc   +2 more sources

Model reduction in mathematical pharmacology: integration, reduction and linking of PBPK and systems biology models [PDF]

, 2018
In this paper we present a framework for the reduction and linking of physiologically based pharmacokinetic (PBPK) models with models of systems biology to describe the effects of drug administration across multiple scales.
Snowden, Thomas J., Tindall, Marcus J., van der Graaf, Piet H.   +2 more
core   +1 more source

Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range [PDF]

, 2016
Solubility can be the absorption limiting factor for drug candidates and is therefore a very important input parameter for oral exposure prediction of compounds with limited solubility.
Bernard Faller, Frank H. Seiler, Jörg Berghausen, Nathalie Gobeau   +3 more
core   +3 more sources

An Overview of Physiologically-Based Pharmacokinetic Models for Forensic Science

Toxics, 2023
A physiologically-based pharmacokinetic (PBPK) model represents the structural components of the body with physiologically relevant compartments connected via blood flow rates described by mathematical equations to determine drug disposition. PBPK models
Kiara Fairman, Me-Kyoung Choi, Pavani Gonnabathula, Annie Lumen, Andrew Worth, Alicia Paini, Miao Li   +6 more
doaj   +1 more source

Modélisation physiologique des interactions métaboliques [PDF]

, 2009
National audienceModeling metabolic interactions between chemicals can be a task of formidable complexity. Here I present a new approach and new tools to facilitate that development.
Bois, Frédéric Y.
core   +3 more sources

Modelling and PBPK Simulation in Drug Discovery [PDF]

The AAPS Journal, 2009
Physiologically based pharmacokinetic (PBPK) models are composed of a series of differential equations and have been implemented in a number of commercial software packages. These models require species-specific and compound-specific input parameters and allow for the prediction of plasma and tissue concentration time profiles after intravenous and ...
Hannah M, Jones, Iain B, Gardner, Kenny J, Watson   +2 more
openaire   +2 more sources

PRT to predict pharmacokinetic profiles as part of a bioequivalence study of the drug deferasirox

Разработка и регистрация лекарственных средств
Introduction. Deferasirox is a complexing drug and belongs to class II according to the biopharmaceutical classification system (BCS), has acidic properties and belongs to subclass “a” (acid).
A. V. Suvorova, P. A. Losenkova, Yu. V. Medvedev, E. A. Malashenko, I. E. Makarenko, A. M. Poluyanov, I. E. Shohin   +6 more
doaj   +1 more source

Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in rats

Particle and Fibre Toxicology, 2022
Background Physiologically based pharmacokinetic (PBPK) modeling is an important tool in predicting target organ dosimetry and risk assessment of nanoparticles (NPs).
Wei-Chun Chou, Yi-Hsien Cheng, Jim E. Riviere, Nancy A. Monteiro-Riviere, Wolfgang G. Kreyling, Zhoumeng Lin   +5 more
doaj   +1 more source

A Mechanistic, Model-Based Approach to Safety Assessment in Clinical Development [PDF]

, 2012
Peer ...
Becker, T, Brosch, M, Görlitz, L, Hampe, J, Kuepfer, L, Laffert, B, Lippert, J, Meyer, M, Neuvonen, PJ, Niemi, M, Schafmayer, C, Schreiber, S, Siegmund, H.-U, von Kampen, O   +13 more
core   +1 more source