Results 71 to 80 of about 16,022 (277)

HD Physiology Project-Japanese efforts to promote multilevel integrative systems biology and physiome research. [PDF]

, 2017
The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size.
for HD physiology project investigators, Furutani, Kazuharu, Kurachi, Yoshihisa, Tsumoto, Kunichika   +3 more
core  

Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two‐treatment‐period, drug‐drug interaction study evaluated the effect of steady‐state asciminib on the pharmacokinetics of atorvastatin.
Matthias Hoch, Wendy Weis, Felix Huth, Seshulatha Jamalapuram, Michelle Quinlan, Amarnath Bandaru, Suleyman Eralp Bellibas, Asmae Mirkou, Shruti Kapoor, Shefali Kakar   +9 more
wiley   +1 more source

Integration of Genome Scale Metabolic Networks and gene regulation of metabolic enzymes with Physiologically Based Pharmacokinetics [PDF]

, 2017
The scope of Physiologically Based Pharmacokinetic (PBPK) modelling can be expanded by assimilation of the mechanistic models of intracellular processes from Systems Biology field.
Al Olama, Alimirah, Arshad, Ay, Bailey, Beste, Blätke, Bordbar, Cannon, Covert, Covert, El-Sankary, Fell, Fisher, Giacomantonio, Gibson, Gille, Goss, Guebila, Heino, Huang, Huang, Huizenga, Jain, Jin, Jones, Kobayashi, Kolodkin, Kotas, Krauss, Lee, Lewis, Mark, Matsuno, Murata, Oakley, Orth, Pascussi, Plant, Reul, Schellenberger, Schilling, Schuster, Shmulevich, Steggles, Stephanopoulos, Varma, Watkins, Wienkers, Wu, Xiao, Zhang   +51 more
core   +2 more sources

Cardiovascular‐Kidney‐Metabolic Syndrome in People With HIV: An Emerging Frontier for Clinical Pharmacology

Clinical Pharmacology &Therapeutics, EarlyView.
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, ART‐associated metabolic effects, and gut dysbiosis amplify risk. Managing CKM increases medication burden, thereby
Aaron S. Devanathan, Thomas D. Nolin
wiley   +1 more source

Chemical risk assessment in food animals via physiologically based pharmacokinetic modeling − Part I: Veterinary drugs on human food safety assessment

Environment International
Veterinary drugs and environmental pollutants can enter food animals and remain as residues in food chains threatening human food safety and health.
Kun Mi, Xue Wu, Zhoumeng Lin
doaj   +1 more source

Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling—A Contribution from the ConcePTION Project

Pharmaceutics, 2023
Women commonly take medication during lactation. Currently, there is little information about the exposure-related safety of maternal medicines for breastfed infants.
Nina Nauwelaerts, Julia Macente, Neel Deferm, Rodolfo Hernandes Bonan, Miao-Chan Huang, Martje Van Neste, David Bibi, Justine Badee, Frederico S. Martins, Anne Smits, Karel Allegaert, Thomas Bouillon, Pieter Annaert   +12 more
doaj   +1 more source

Development of a Physiologically Based Model of Bilirubin Metabolism in Health and Disease and Its Comparison With Real-World Data. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Bilirubin is a breakdown product of erythrocytes and plays a crucial role in elimination of heme‐containing proteins. After its synthesis in the reticuloendothelial system, unconjugated bilirubin is released into plasma and taken up into the liver.
Sayin AZ, Kuepfer L.
europepmc   +2 more sources

Development of a physiologically based kinetic model for 99m-Technetium-labelled carbon nanoparticles inhaled by humans [PDF]

, 2009
International audienceParticulate air pollution is associated with respiratory and cardiovascular morbidity and mortality. Recent studies investigated whether and to which extent inhaled ultrafine particles are able to translocate into the bloodstream in
Bois, Frédéric Y., Brochot, Céline, Hoet, Peter, Nemmar, Abderrahim, Pery, Alexandre R.R.   +4 more
core   +2 more sources

ZeroPM piece 12 PBPK modelling

ZeroPM Pieces, 2022
ZeroPM piece 12 about PBPK modelling. The presentation can be viewed as a film on the ZeroPM youtube channel.
openaire   +1 more source

Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations

CPT: Pharmacometrics & Systems Pharmacology, 2022
There has been a significant increase in the use of physiologically based pharmacokinetic (PBPK) models during the past 20 years, especially for pediatrics.
Trevor N. Johnson, Ben G. Small, Karen Rowland Yeo   +2 more
doaj   +1 more source