Results 91 to 100 of about 12,447 (257)

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, EarlyView.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices

Exploration, EarlyView.
This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang, Ziwei Liang, Jiapu Wang, Zongyi Li, Shaojie Wang, Yan Wei, Xin Xie, Di Huang   +7 more
wiley   +1 more source

Ultrasmall Au10–12 Nanoclusters: A Novel Platform for 223Ra‐Targeted Tumor α‐Therapy

Exploration, EarlyView.
Encapsulating 223Ra in Au10‐12 nanoclusters and functionalizing them with RGD peptides enables targeted α‐therapy and immune microenvironment remodeling in non‐osseous tumors like triple‐negative breast cancer. This study establishes a foundational framework for novel 223Ra‐labeled α‐radiopharmaceuticals and shows strong potential for clinical ...
Yifei Jiang, Huizhen Yang, Guoping Jia, Wangxi Hai, Rongyi Huang, Peng Wang, Min Zhang, Danni Li, Yizhou Chen, Xiao Li, Biao Li, Chunfu Zhang   +11 more
wiley   +1 more source

Optimizing ribociclib dosing in breast cancer with brain metastasis patients using a physiologically based pharmacokinetic model

BMC Cancer
Objective This study aimed to determine the optimal dosing strategy for ribociclib (RIB) in patients with breast cancer and brain metastasis (BCBM) by using a developed and validated physiologically based pharmacokinetic (PBPK) model.
Chao Zhang, Shan Li, Jiawei Ren, Xiaohui Wen   +3 more
doaj   +1 more source

Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109769/1/cptclpt201378 ...
Bai, J P F, Brouwer, K L R, Chu, X, Elsby, R, Fenner, K, Galetin, A, Korzekwa, K, Lai, Y, Matsson, P, Moss, A, Nagar, S, Polli, J W, Rosania, G R, Sugiyama, Y   +13 more
core   +2 more sources

Sotalol Dose Optimization for Fetal Tachycardia: A Pregnancy Physiologically Based Pharmacokinetic Model Study

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To establish an optimized sotalol dosing strategy for fetal tachycardia using a pregnancy physiologically based pharmacokinetic (PBPK) model. Method A verified PBPK model was developed incorporating pregnancy‐induced physiological changes and placental transfer.
Hedwig van Hove, Joyce E. M. van der Heijden, Anne van Uden, Violette M. G. J. Gijsen, Rick Greupink, Saskia N. de Wildt, Joris van Drongelen   +6 more
wiley   +1 more source

Application of Physiologically‐Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin

CPT: Pharmacometrics & Systems Pharmacology, 2019
Moxifloxacin is a widely used fluoroquinolone for the treatment of complicated intra‐abdominal infections. We applied physiologically‐based pharmacokinetic (PBPK) and population pharmacokinetic (popPK) modeling to support dose selection in pediatric ...
Stefan Willmann, Matthias Frei, Gabriele Sutter, Katrin Coboeken, Thomas Wendl, Thomas Eissing, Jörg Lippert, Heino Stass   +7 more
doaj   +1 more source

Addressing human variability in next-generation human health risk assessments of environmental chemicals [PDF]

, 2012
International audienceCharacterizing variability in the extent and nature of responses to environmental exposures is a critical aspect of human health risk assessment.
Beal SL, Chiu WA, Dale Hattis, Frederic Y. Bois, Ivan Rusyn, Kathryn Z. Guyton, Lauren Zeise, Weihsueh A. Chiu   +7 more
core   +4 more sources

Contaminants of emerging concern in agricultural soils: Current understanding, overlooked issues, and future priorities

PLANTS, PEOPLE, PLANET, EarlyView.
Contaminants of emerging concern (CECs) in agriculture represent a growing global challenge for food safety and public health. In this review, we synthesized evidence on how substances such as pharmaceuticals, microplastics, and per‐ and polyfluoroalkyl substances (PFAS) enter soils, accumulate in crops, and affect ecological and human health. We found
Laura J. Carter, Evyatar Ben Mordechay, Benny Chefetz, Zeyou Chen, Xinyi Cui, Jay Gan, Hui Li, Audrey Moores, Xiaoyu Gao   +8 more
wiley   +1 more source

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source