Results 111 to 120 of about 8,529 (239)

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Evaluation of the PK/PD Changes on MASLD‐Related Population—An Example From Simultaneous Acetaminophen Parent‐Metabolite PBPK/PD Modeling

CPT: Pharmacometrics & Systems Pharmacology
Patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) may exhibit altered pharmacokinetics (PK) and pharmacodynamics (PD) of drugs compared with healthy populations.
Shanshan Zhao, Lan Zhang
doaj   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso, Ronald Kadada Karyaburo, Jackson K. Mukonzo, Ene I. Ette   +3 more
wiley   +1 more source

Physiologically based pharmacokinetic (PBPK) model fit and validation.

, 2019
Physiologically based pharmacokinetic (PBPK) model simulations (lines) and experimental blood plasma profile (circles) of IFN-α in humans. A) Experimental results of Wills et al. [36] and the corresponding fit.
Jörg Lippert (124210), Julian Brandl (3840103), Sven Sahle (222858), Lars Küpfer (6331121), Priyata Kalra (6331118), Christoph Niederalt (535381), Ursula Kummer (437648), Thomas Gaub (223638)   +7 more
core   +1 more source

The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2203-2211, July 2026.
Abstract Aim The quantitative effect of several inhibitory drugs on the development of adverse drug reactions (ADRs) is currently difficult to estimate. Our aim was to identify metabolic pathways, which, when inhibited, increase the risk for certain ADRs, and to use this system to consider comedication at individual level. Methods Data of a prospective
Judith Berres, Justyna Wozniak, Hannah Fölsch, Anja Knueppel‐Ruppert, Verena Graeff, Andrea Kriegisch‐Stumpf, Harald Dormann, Julia C. Stingl, Katja S. Just   +8 more
wiley   +1 more source

Modeling the Distribution and Metabolism of the Phytoestrogen Genistein in Rats

, 2003
Genistein is an endocrine-active compound found naturally in soy products. It has been linked to various health effects, both beneficial and adverse. The liver is a major site of genistein transformation.
Zager, Michael Gary
core  

Physical, chemical parameters and in vitro metabolic parameters amoxicillin used in PBPK model building.

, 2016
Physical, chemical parameters and in vitro metabolic parameters amoxicillin used in PBPK model building.
Yunfan Zhao (2901413), Xiaoqiang Xiang (2901410), Tao Tao (19313), Xuyu Chai (2901416), Hongyu Chai (788005), Yang Li (7082), Jin Li (119007), Yan Zhao (58882)   +7 more
core   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 43-54, July 2026.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Lumping von PBPK-Modellen und Systembiologie

, 2011
In drug discovery and development, pharmacokinetic and pharmacodynamic modeling are successfully applied to analyze and predict the time course of drug concentration and drug effect in the patient.
Pilari, Sabine
core   +1 more source