Results 121 to 130 of about 13,844,580 (194)
Ecotoxicology and Environmental SafetyReliable prediction of internal doses, especially systemic blood concentrations, is crucial for exposure science and environmental health risk assessment. While traditional physiologically based pharmacokinetic (PBPK) models provide mechanistic insights,
Laurent Simon
doaj +1 more source
Model Master File Framework: A Regulatory Path Advancing Modeling and Simulation Applications
Clinical and Translational Science, Volume 19, Issue 10, October 2026.ABSTRACT To advance drug product development, regulatory decision making, and improve patient care, FDA has committed to the quantitative medicine paradigm that involves, among others, quantitative in silico methodologies and tools developed based on nonclinical, clinical, and real‐world sources. In this Perspective, Model Master File (MMF) submissions
Eleftheria Tsakalozou +4 more
wiley +1 more source
A minimal PBPK model to accelerate preclinical development of drugs against tuberculosis. [PDF]
Front Pharmacol, 2023 Reali F +8 more
europepmc +1 more source
Fruquintinib: Mechanism of Action, Clinical, and Translational Science
Clinical and Translational Science, Volume 19, Issue 10, October 2026.ABSTRACT Fruquintinib is a highly selective, oral inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3) that was approved, including in China, the United States, and the European Union, for the treatment of previously treated metastatic colorectal cancer (mCRC).
Xiaofei Zhou +7 more
wiley +1 more source
, 1989 Bimonthly magazine discussing topics related to aviation and model airplane engines including collecting, restoring, maintaining, and identifying engines, along with ...
The Model Museum
core
We present pbpk-lite, an open-source physiologically based pharmacokinetic (PBPK) model implemented in Python for simulating the absorption, distribution, metabolism, and elimination of Δ9-tetrahydrocannabinol (THC) in humans.
Patricija Zupan +3 more
core +1 more source
Harnessing Quantitative Medicine to Advance Oncology Drug Development
Clinical and Translational Science, Volume 19, Issue 10, October 2026.ABSTRACT Oncology drug development continues to have a high attrition rate despite major advances in therapeutic modalities such as antibody‐drug conjugates, bispecific antibodies, cell therapies, and cancer vaccines. Critical development decisions are often made under substantial uncertainty, creating a need for quantitative approaches that integrate ...
Benjamin Wu +3 more
wiley +1 more source
Clinical and Translational Science, Volume 19, Issue 10, October 2026.ABSTRACT Lung cancer predominantly affects older adults who already experience comorbidities and are at increased risk of drug–drug interactions (DDIs) due to polypharmacy. Traditional DDI assessments often do not fully capture complex co‐medication patterns observed in real‐world practice due to the risk of introducing confounding factors.
Mareena Biju +6 more
wiley +1 more source
The First Physiologically Based Pharmacokinetic (PBPK) Model for an Oral Vaccine Using Alpha-Tocopherol as an Adjuvant. [PDF]
Pharmaceutics, 2023 Saldanha L, Vale N.
europepmc +1 more source
Translational PBPK Modeling and Exposure‐Response Analysis of AT‐RvD1 for Treating Sjögren's Disease
Clinical and Translational Science, Volume 19, Issue 10, October 2026.ABSTRACT Sjögren's disease (SD) is an autoimmune condition characterized by chronic inflammation and impaired secretory function of the salivary glands (SG). The proresolving lipid mediator AT‐RvD1 restores SG function in SD‐like mice; however, its tissue pharmacokinetics, exposure‐response relationships, and human dose predictions remain poorly ...
Venkata K. Yellepeddi +3 more
wiley +1 more source