Results 121 to 130 of about 4,447,834 (239)
FASEB BioAdvances, Volume 8, Issue 9, September 2026.Supraphysiological 25(OH)D3 and calcipotriol induced ROS accumulation or redox disturbance, increased mitochondrial membrane depolarization, reduced antioxidant enzyme activity, and caused apoptotic cell death in HeLa cells. ABSTRACT Cervical cancer remains a major global health challenge, necessitating continued advances in therapeutic strategies ...
Hoi Ching Cherry Chan +5 more
wiley +1 more source
Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling
Andrology, Volume 14, Issue 6, Page 1831-1846, September 2026.ABSTRACT Background Diabetes mellitus‐induced erectile dysfunction (DMED) is a common and debilitating vascular‐neurogenic complication of diabetes. The poor responsiveness of DMED patients to phosphodiesterase type‐5 inhibitors underscores the need for therapies capable of restoring both endothelial integrity and cavernous nerve function.
Sen Fu +7 more
wiley +1 more source
Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases
Cell Proliferation, Volume 59, Issue 9, September 2026.m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du +7 more
wiley +1 more source
TCDD induces premature senescence in PC12 neuronal cells.
, 2014 (A) Upper panel: PC12 cells were treated with DMSO or 1, 10, 50 and 100 nM TCDD for 72 h and then subjected to an SA-β-Gal staining assay. Lower panel: PC12 cells were treated with 50 nM TCDD for 0, 24, 48, 72 and 96 h and then subjected to an SA-β-Gal ...
Lingwei Liang (526592) +8 more
core +1 more source
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies
Traffic, Volume 27, Issue 3, September 2026.Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby +3 more
wiley +1 more source
Overexpression of SH2B1β enhances wound healing of differentiated PC12 cells.
, 2012 PC12-GFP, PC12-SH2B1β cells (A–D) and PC12-GFP, PC12-SH2B1β, PC12-(Δ150–200), PC12-(Δ200–268) cells (F) were differentiated by 50 ng/ml NGF treatment for 8 days. On day 8, differentiated cells were scraped by P10 tips and defined as healing day 0.
Nan-Yuan Teng (169098) +5 more
core +1 more source
, 2012 (A) Permeability to water and glycerol of wild type PC12 cells and PC12 transfected with either AQP1 or AQP3.
Antonella Ciancetta (164206) +8 more
core +1 more source
Expression of RabGEF1 in PC12 cells stimulated with NGF.
, 2015 A) Analysis of RabGEF1 mRNA expression in PC12 cells stimulated with NGF. PC12 cells were stimulated with NGF (50 ng/ml) for the indicated time periods and RNA was extracted and analyzed using Northern blot analysis.
Janet Kalesnikoff (828869) +4 more
core +1 more source
Effect of intrabody expression on the NGF-induced differentiation of PC12 cells.
, 2013 (A) PC12 cells transfected with the αphOx-KDEL construct. (B) PC12 cells transfected with the SH325-G7 construct. (C) PC12 cells transfected with SH325-G7-KDEL construct. (D) Percentage of differentiated PC12 cells in the cells transfected with different
Andrea L. J. Marschall (334275) +8 more
core +1 more source
Interleukin-6-induced tyrosine phosphorylation of phospholipase C-gamma 1 in PC12 cells
, 2019 Phospholipase C (PLC)-gamma 1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-6 ...
Choi, I +5 more
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