Results 111 to 120 of about 4,447,834 (239)

AGS-IV protects against glutamate-induced neurotoxicity in PC12 cells.

, 2015
(A) Dose-dependent cell death was observed after the cells were treated with different concentrations glutamate for 24 h. (B) Effects of 50 μM AGS-IV, 6-O-β-D-glu CAG, 3-O-β-D-xyl CAG, and CAG on glutamate-induced PC12 cell neurotoxicity. (C) Survival of
Bingyang Chen (736971), Huizi Jin (736975), Hu Yuan (736972), Jing Zhao (21160), Xing Yuan (736973), Na Gao (137976), Rongcai Yue (736970), Weidong Zhang (68880), Guozhen Wu (736974), Lei Shan (435731), Xia Li (14984), Weiwei He (32469)   +11 more
core   +1 more source

Study of High Glucose-Induced Apoptosis in PC12 Cells: Role of Bax Protein

Journal of Pharmacological Sciences, 2007
Hyperglycemia, which occurs under the diabetic condition, induces serious diabetic complications. Diabetic neuropathies, affecting the autonomic, sensory, and motor peripheral nervous system, are among the most frequent complications of diabetes.
Ali M. Sharifi, Seyed Hadi Mousavi, Mona Farhadi, Bagher Larijani   +3 more
doaj   +1 more source

Icariside II in Neurological Disorders: Mechanistic Insights Into Alzheimer's Disease, Cerebral Ischemia and Parkinson's Disease

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The graphical abstract represents the underlying neuroprotective potential of ICS II against Alzheimer's disease, Cerebral ischemia and Parkinson disease. ICS II downregulates ROS production, inflammation, mitochondrial dysfunction and apoptosis along with regulating their key signalling pathways.
Ashutosh Solanki, Khushi Sharma, Jagrati Jain, Niraj Kumar Singh, Praveen T. Krishnamurthy   +4 more
wiley   +1 more source

Lipopolysaccharide and Morphine-3-Glucuronide-Induced Immune Signalling Increases the Expression of Polysialic Acid in PC12 Cells

, 2020
© 2019, Springer Science+Business Media, LLC, part of Springer Nature. Polysialic acid (polySia), a long homopolymer of 2,8-linked sialic acids, is abundant in the embryonic brain and is restricted largely in adult brain to regions that exhibit ...
Everest-Dass, A., Iqbal, S, Iqbal, S., Moh, E.S.X., Packer, N.H., Everest-Dass, AV, Hutchinson, MR, Packer, NH, Moh, ESX, Sayyadi, N., Sayyadi, N, Parker, LM, Hutchinson, M.R., Parker, L.M.   +13 more
core   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 196-219, September 2026.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

Subcellular Distribution of S-Nitrosylated H-Ras in Differentiated and Undifferentiated PC12 Cells during Hypoxia

Cell Journal, 2017
Objective Hypoxia or exposure to excessive reactive oxygen or nitrogen species could induce S-nitrosylation of various target proteins, including GTPases of the Ras-superfamily.
Tamar Barbakadze, Galina Goloshvili, Nana Narmania, Elene Zhuravliova, David Mikeladze   +4 more
doaj   +1 more source

Mitochondria as the Hub of Apoptosis: A Comprehensive Insight From Mitochondria to Interactions With Other Organelles

MedComm, Volume 7, Issue 9, September 2026.
Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan, Jinming Zhao, Rong Wang, Yue Shi, Zaozao Chen, Yixuan Ma, Na Li, Wenqing Duan, Duo Lin, Chunxiang Zhang   +9 more
wiley   +1 more source

Effect of neural stem cells on apoptosis of PC12 cells induced by serum deprivation.

, 2007
Neural stem cells (NSCs) have a bright application prospect to be used to treat neurodegenerative diseases due to their capacity to give rise to the appropriate cell types when they are grafted.
Zhu, L, Liu, T, Ge, D, Cui, Zhanfeng, Li, X, Cui, Z, Song, K, Guan, S   +7 more
core   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

No Significant Secondary Structural Change of α‐Synuclein Monomer by Site‐Specific DOPA or Phosphorylation Introduction in Its C‐Terminal Region

Journal of Peptide Science, Volume 32, Issue 9, September 2026.
Site‐specifically modified α‐synuclein containing DOPA or phosphorylation was prepared by ligation of a bacterially expressed N‐terminal polypeptide and a synthetic C‐terminal modified peptide. ABSTRACT α‐Synuclein (αSyn) is a major component of pathogenic Lewy bodies and Lewy neurites and is closely associated with Parkinson's disease.
Tatsuhito Matsuo, Isao Suetake, Mariko Kimura, Satoshi Hashimoto, Koichi Matsuo, Sakiko Matsumoto, Shinji Hirotsune, Hironobu Hojo   +7 more
wiley   +1 more source