Results 91 to 100 of about 4,447,834 (239)

Dual effect of nerve growth factor on cell death of PC12 cells induced by serum deprivation

, 2019
The effect of nerve growth factor (NGF) on the cell death of PC12 cells that is induced by serum deprivation was examined in the floating and attached cells to the extracellular matrix. NGF suppressed cell death occurred in the floating cells.
정준모, 허규정
core   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

In vitro effects of fetal rat cerebrospinal fluid on viability and neuronal differentiation of PC12 cells

Fluids and Barriers of the CNS, 2012
Background Fetal cerebrospinal fluid (CSF) contains many neurotrophic and growth factors and has been shown to be capable of supporting viability, proliferation and differentiation of primary cortical progenitor cells.
Nabiuni Mohammad, Rasouli Javad, Parivar Kazem, Kochesfehani Homa M, Irian Saeid, Miyan Jaleel A   +5 more
doaj   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus‐Dependent Learning and Memory Impairments

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley   +1 more source

Interaction of gold nanoparticles with neurons

, 2013
In the last few decades, advances in nanotechnology have resulted in the production and use of inorganic nanoparticles (NPs). These NPs have been used commercially for a range of applications, particularly in the biomedical field, based on their ...
Christofidou, A.
core   +1 more source

A Novel Antioxidant Peptide Cath‐Np Derived from Nanorana parkeri Attenuates UVB‐Induced Skin Photodamage in Mice

Integrative Zoology, EarlyView.
Schematic representation of Cath‐Np as an antioxidant suppressing acute skin damage caused by ultraviolet B (UVB) radiation in mice. Cath‐Np inhibits the activation of p53 and mitogen‐activated protein kinase pathways while it activates the Nrf2 pathway by its strong antioxidant effects, and accordingly suppresses the expression of inflammatory factors
Hang Liao, Xiaoxiao Shen, Jinwei Chai, Kai wang, Jiena Wu, Jianxi Yang, Ming Chen, Guoxiang Mo, Xueqing Xu   +8 more
wiley   +1 more source

Neurotrophic effects of NK-4 in PC12 cells.

, 2013
(A) Effect of NK-4 on PC12 cell growth. PC12 cells were raised in D-MEM containing 10% FBS for 72 hr in the presence or absence of NK-4. The number of cells was assessed by alamarBlue assay.
Shigeharu Fukuda (336238), Shigeyuki Arai (336233), Hitomi Ohta (336232), Kenji Akita (336235), Tsunetaka Ohta (336237)   +4 more
core   +1 more source

Synergistic Neuroprotective Effect of Endogenously-Produced Hydroxytyrosol and Synaptic Vesicle Proteins on Pheochromocytoma Cell Line against Salsolinol

Molecules, 2020
Oxidative stress triggers a lethal cascade, leading to Parkinson’s disease by causing degeneration of dopaminergic neurons. In this study, eight antioxidants were screened for their neuroprotective effect on PC12 cells (pheochromocytoma cell line) under ...
Robina Manzoor, Aamir Rasool, Maqbool Ahmed, Ullah Kaleem, Lucienne Nneoma Duru, Hong Ma, Yulin Deng   +6 more
doaj   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source