Results 71 to 80 of about 4,447,834 (239)

Efeitos biológicos e moleculares de compostos orgânicos sintéticos de selênio sobre o sistema nervoso central e neurotoxicidade do manganês [PDF]

, 2009
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciencias Biológicas. Programa de Pós-Graduação em Neurociências.No presente estudo foi analisado o potencial antioxidante e protetor do composto orgânico sintético de selênio difenil ...
Posser, Thaís
core  

Iron enhances NGF-induced neurite outgrowth in PC12 cells

, 2019
Rat pheochromocytoma 12 (PC12) cells undergo neuronal differentiation in response to nerve growth factor (NGF). NGF-induced differentiation involves a number of protein kinases, including extracellular signal-regulated kinase (ERK). We studied the effect
정준모, 오억수, 허규정
core   +1 more source

Translational Control of Ribosomal Protein L4 mRNA Is Required for Rapid Neurite Regeneration

Neurobiology of Disease, 2000
Under some circumstances neurons can be primed to rapidly regenerate injured neuritic processes independent of new gene expression. Such transcription-independent neurite extension occurs in adult rat sensory neurons cultured after sciatic nerve crush ...
Jeffery L. Twiss, Deanna S. Smith, Bieshia Chang, Eric M. Shooter   +3 more
doaj   +1 more source

Dexmedetomidine protects PC12 cells from oxidative damage through regulation of miR-199a/HIF-1α

Artificial Cells, Nanomedicine, and Biotechnology, 2020
Background Although dexmedetomidine (Dex) has a significant neuroprotective effect in various nerve-damage models, the exact mechanism of which Dex protects cells from oxidative damage is not fully clear. This article recommended the protective effect of
Ling Wu, Yalin Xi, Qinglong Kong
doaj   +1 more source

Inhibition of neuronal phenotype by PTEN in PC12 cells [PDF]

Proceedings of the National Academy of Sciences, 2004
The mechanisms of neuronal differentiation in PC12 cells are still not completely understood. Here, we report that the tumor suppressor PTEN has a profound effect on differentiation by affecting several pathways involved in nerve growth factor (NGF) signaling.
Sergei, Musatov, Jill, Roberts, Andrew I, Brooks, John, Pena, Simone, Betchen, Donald W, Pfaff, Michael G, Kaplitt   +6 more
openaire   +2 more sources

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

Neferine inhibits Aβ1-42-induced PC12 cell injury through regulating the expression of miR-29a-3p/AQP4 [PDF]

Jichu yixue yu linchuang, 2020
Objective To explore the role and molecular mechanism of Neferine (Nef) on PC12 cells injury induced by Aβ1-42. Methods PC12 cells were divided into control group, model group(4 μg/mL Aβ1-42 cultured for 24 h) and low, medium and high-dose neferine ...
ZENG Li-min, LU Zhao-hui, ZHOU Li-ping, ZHU Chao-xia
doaj  

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Neuronal Differentiation of Human Mesenchymal Stem Cells Using Exosomes Derived from Differentiating Neuronal Cells. [PDF]

PLoS ONE, 2015
Exosomes deliver functional proteins and genetic materials to neighboring cells, and have potential applications for tissue regeneration. One possible mechanism of exosome-promoted tissue regeneration is through the delivery of microRNA (miRNA).
Yuji S Takeda, Qiaobing Xu
doaj   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source