Results 51 to 60 of about 4,447,834 (239)
Role of PARP-1 in mitochondroal DNA damage induced by rotenone in PC12 cells
Di-san junyi daxue xuebao, 2019 Objective To explore the effect of poly (ADP-ribose) polymerase-1 (PARP-1) on mitochondrial DNA (mtDNA) damage induced by rotenone in rat adrenal medulla pheochromocytoma PC12 cells. Methods PC12 cells were treated with various dose of rotenone.
XIAO Jingsong, HOU Guizhong, SAI Yan
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave +8 more
wiley +1 more source
Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives
Advanced Materials, EarlyView.Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi +4 more
wiley +1 more source
Ferulic acid protects PC12 neurons against hypoxia by inhibiting the p-MAPKs and COX-2 pathways [PDF]
Iranian Journal of Basic Medical Sciences, 2015 Objective(s):Hypoxia induces cellular oxidative stress that is associated with neurodegenerative diseases. Here, the protective effects of ferulic acid (FA) on hypoxia-induced neurotoxicity in PC12 cells were evaluated.
Wen-Chieh Lin +2 more
doaj
Biomolecules, 2022 Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment.
RuoLi Chen +2 more
doaj +1 more source
Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization
Advanced Materials, EarlyView.A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab +8 more
wiley +1 more source
Imidazoline receptor antisera-selected protein: a unique modulator of neuronal differentiation. [PDF]
, 2008 The imidazoline I1 receptor (I1-R) is a novel receptor found primarily in the brain and nervous tissue where it modulates neurotransmission. It is named for its high affinity for compounds with an imidazoline structure such as the anti-hypertensive drugs,
Dehle, Francis Christian
core
Inhibition of Proteasome Activity by Tyropeptin A in PC12 Cells
Bioscience, Biotechnology, and Biochemistry, 2002 Tyropeptin A, a potent proteasome inhibitor not reported before, was produced by Kitasatospora sp. MK993-dF2. In this study, we investigated the effects of tyropeptin A on proteasome activity in PC12 cells. Tyropeptin A inhibited the intracellular proteasome activity in a dose-dependent way and seemed to cause neurite outgrowth.
MOMOSE, Isao +3 more
openaire +2 more sources
Advanced Materials Technologies, EarlyView.Coaxial melt electrowriting is established to produce dual‐property microfibers with diameters spanning 1.6–29.2 µm. Stable coaxial laminar flow is preserved under electrohydrodynamic thinning, enabling controlled binary and gradient material switching within individual continuous fibers.
Patrick C. Hall +11 more
wiley +1 more source
Cytosolic sialidase Neu2 upregulation during PC12 cells differentiation. [PDF]
, 2004 The cytosolic sialidase Neu2 is known to be involved in myoblast differentiation. Here, we observed a Neu2 transcriptional induction during nerve growth factor, fibroblast growth factor 2 and epidermal growth factor treatments of PC12 cells, a favored ...
Colombo, F. +14 more
core +2 more sources