Results 101 to 110 of about 49,971 (256)
Acta Obstetricia et Gynecologica Scandinavica, EarlyView.A systematic review of 33 gestational diabetes risk prediction models found fair discrimination but significant methodological weaknesses. With 69% of studies at high risk of bias, future research must adopt rigorous, scalable validation strategies to enhance clinical utility.
Beminate Lemma Seifu +5 more
wiley +1 more source
Early‐ vs. late‐onset gestational diabetes: Differential impact on maternal and neonatal outcomes
Acta Obstetricia et Gynecologica Scandinavica, EarlyView.Early‐onset gestational diabetes mellitus (diagnosed before 20 weeks) identifies a clinically higher‐risk phenotype than late‐onset GDM (24–28 weeks), with greater insulin requirement and higher adjusted risks of preeclampsia, cesarean delivery, preterm birth, and adverse neonatal outcomes.
Baolai Li +3 more
wiley +1 more source
PCOS and risk of fractures [PDF]
Journal of Bone and Mineral Metabolism, 2018 Yueh-Han Hsu, Hsin-Yi Yang
openaire +2 more sources
PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes
British Journal of Pharmacology, EarlyView.Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier +9 more
wiley +1 more source
Targeting hexokinase 2 to induce breast cancer cell senescence
British Journal of Pharmacology, EarlyView.Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof +8 more
wiley +1 more source
Cardiometabolic Risk in First Degree Relatives of Women With Polycystic Ovary Syndrome (PCOS)
Clinical Endocrinology, EarlyView.ABSTRACT Objective Polycystic ovary syndrome (PCOS) is a common multisystem disorder with reproductive, cardiometabolic and psychological implications. Genetic factors play a role in the pathogenesis of PCOS. We sought to investigate the cardiometabolic health of first degree relatives (FDR) of women with PCOS.
Su Jen Chua +8 more
wiley +1 more source
Diabetic Medicine, EarlyView.Abstract Aims Investigate the relationship of gestational diabetes (GDM) risk for specific migrant groups compared to the Australian born of each ethnic group and length of residence (LOR) in Australia. Methods Retrospective observational cohort study from June 2020 to November 2023 at 10 Australian hospitals.
Sheila Pham +12 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aim In December 2022, semaglutide injections for weight management were marketed in Denmark. Pre‐marketing trials documented high efficacy when adherence to the treatment and the recommended dose titration schedule was followed. This study aimed to describe real‐world use of semaglutide, including dose titration, discontinuation patterns and ...
Mie Dyberg Skandov +7 more
wiley +1 more source
International Endodontic Journal, EarlyView.ABSTRACT Aim The aim was to characterize the taxonomic and functional composition of the microbiome involved in primary endodontic infections and to evaluate their association with the periapical lesion size using shotgun metagenomic sequencing. Methodology Samples from primary root canal infections diagnosed with apical periodontitis were analysed ...
Virginia Pérez‐Carrasco +5 more
wiley +1 more source