Results 81 to 90 of about 142,502 (333)

The effect of atorvastatin on pancreatic beta cell requirement in women with polycystic ovary syndrome [PDF]

, 2017
Background There is an increased risk of developing T2DM in women with polycystic ovary syndrome (PCOS) and there is evidence that statins improve metabolic parameters in these patients.
Atkin, Stephen L., Coady, Anne Marie, Kilpatrick, Eric S., Sathyapalan, Thozhukat   +3 more
core   +2 more sources

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

The role of androgen and its related signals in PCOS

Journal of Cellular and Molecular Medicine, 2020
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. However, the underlying pathogenic mechanisms have not been completely understood. Hyperandrogenism is an important clinic feature in patients with PCOS,
Wenting Ye, Tingting Xie, Yali Song, Lili Zhou   +3 more
semanticscholar   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Integrated multi-omics analysis reveals complement component 3 as a central driver of immune dysregulation in polycystic ovary syndrome

Frontiers in Endocrinology
BackgroundPolycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder with a complex pathophysiology, affecting various aspects of women’s health.
Xuanpeng Zhao, Qingyan Meng, Shuang Liu, Linqi Cheng, Baoshan Li, Dongkai Cheng   +5 more
doaj   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Polycystic Ovary Syndrome and Reproductive Health: A Comprehensive Review

Clinical and Experimental Obstetrics & Gynecology
Objectives: Polycystic ovary syndrome (PCOS) is a prevalent and intricate endocrine disorder that impacts women of reproductive age. It is marked by various symptoms, including menstrual irregularities, hyperandrogenism, and metabolic ...
Ramadan S. Hussein, Salman Bin Dayel, Othman Abahussein   +2 more
doaj   +1 more source

Vertical Integration from the Large Hilbert Space

, 2017
We develop an alternative description of the procedure of vertical integration based on the observation that amplitudes can be written in BRST exact form in the large Hilbert space. We relate this approach to the description of vertical integration given
Erler, Theodore, Konopka, Sebastian
core   +1 more source

Analytic Approximations for Three Neutrino Oscillation Parameters and Probabilities in Matter [PDF]

, 2001
The corrections to neutrino mixing parameters in the presence of matter of constant density are calculated systematically as series expansions in terms of the mass hierarchy $\dm{21}/\dm{31}$.
A. Cervera, A. Cervera, A. S. Joshipura, C. W. Kim, G. L. Fogli, G. L. Fogli, G. L. Fogli, H. W. Zaglauer, J. Arafune, J. C. D’Olivo, J. N. Bahcall, K. Dick, L. Wolfenstein, L. Wolfenstein, M. Apollonio, M. Freund, Martin Freund, P. F. Harrison, P. I. Krastev, S. Geer, S. P. Mikheyev, S. P. Mikheyev, S. T. Petcov, S. T. Petcov, S. Toshev, S. Toshev, S. Toshev, T. K. Kuo, T. Ohlsson, T. Ohlsson, T. Ohlsson, V. Barger, V. M. Aquino   +32 more
core   +2 more sources

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source