Results 41 to 50 of about 65,658 (308)

Modelling phase-change integrated photonic devices [PDF]

open access: yes, 2018
Available from E\PCOS via the link in this recordWe report the progress made on the development of a self-consistent 3-dimensional simulation framework, yielding the time and spatially resolved electric field, temperature and material phase, for ...
Cheng, Z   +8 more
core  

The impact of Polycystic Ovary Syndrome (PCOS) on quality of life: exploration, measurement and intervention. [PDF]

open access: yes, 2016
Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders amongst women, estimated to affect one out of 10 women. Symptoms include infertility, obesity, alopecia, acne, hirsutism and menstrual irregularities.
Williams, Sophie
core   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

open access: yesAdvanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li   +22 more
wiley   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

open access: yesAdvanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li   +15 more
wiley   +1 more source

Insulin Resistance in PCOS

open access: yesEndocrine, 2006
Polycystic ovary syndrome (PCOS) is the commonest endocrinopathy affecting women of reproductive age, manifested with a variety of clinical signs, none of which is pathognomonic. The association of insulin resistance and reproductive abnormalities with clinical hyperandrogenism in a woman was first demonstrated by Achard and Thiers in the "diabetes of ...
openaire   +3 more sources

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

open access: yesAdvanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi   +13 more
wiley   +1 more source

Awareness of young female for polycystic ovarian syndrome: a community survey

open access: yesAl-Azhar Assiut Medical Journal
Background and aim The most common disease condition among young females is polycystic ovarian syndrome (PCOS). The woman usually enters the hospital in advance due to a lack of awareness, which is very fatal for their maternity life.
Kusum Kumari   +3 more
doaj   +1 more source

Prevalence of endocrine disorders in patients with suspected polycystic ovary syndrome [PDF]

open access: yes, 2023
openLa sindrome dell’ovaio policistico (PCOS) è il disturbo endocrinologico più frequente nelle donne in età fertile e si caratterizza per la presenza di segni e sintomi di iperandrogenismo e disfunzione ovarica che interagiscono tra loro generando ...
GENTILETTI, ELISA
core  

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

open access: yesAdvanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan   +11 more
wiley   +1 more source

Targeting steroid receptor coactivators for the treatment of benign female reproductive disorders

open access: yesEndocrine Connections
Steroid receptor coactivators (SRCs) are master regulators of nuclear receptor signaling and play essential roles in female reproductive physiology. By integrating steroid hormone signaling with growth factors and metabolic pathways, SRC-1, SRC-2, and ...
Yuri Park   +4 more
doaj   +1 more source

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