Results 21 to 30 of about 49,971 (256)

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Advances in the management of osteopenia: a case series

Journal of Medical Case Reports
Background Osteopenia is a pre-pathological condition characterized by reduced bone mineral density that may lead to increased fracture risk and to the onset of osteoporosis. Standard treatments for managing osteopenia include supplementation of calcium,
Maurizio Nordio, Roberto Baldelli
doaj   +1 more source

Women with PCOS have a heightened risk of cardiometabolic and cardiovascular diseases: statement from the Experts Group on Inositol in Basic and Clinical Research and PCOS (EGOI-PCOS) and Italian Association of Hospital Cardiologists (ANMCO)

Frontiers in Cardiovascular Medicine
In recent years, the prevalence of polycystic ovary syndrome (PCOS) has gradually increased, and the investigation of the causal factors influencing etiopathogenesis is attracting attention.
Giovanna Geraci, Carmine Riccio, Fabrizio Oliva, Fabrizio Oliva, Fabrizio Oliva, Domenico Gabrielli, Domenico Gabrielli, Furio Colivicchi, Massimo Grimaldi, Fabio Facchinetti, Fabio Facchinetti, Vittorio Unfer, Vittorio Unfer   +12 more
doaj   +1 more source

SCREENING OF PRE-DIABETES IN PATIENTS PRESENTING WITH POLYCYSTIC OVARIAN SYNDROME: A TERTIARY CARE EXPERIENCE

Khyber Medical University Journal, 2021
OBJECTIVE: To screen the females presenting with Polycystic Ovarian Syndrome (PCOS) for underlying pre-diabetes and to correlate pre-diabetes with the various diagnostic criteria of PCOS.
Akhtar Hussain, Sobia Sabir Ali, Ibrar Ahmad, Muhammad Nawaz Khan, Syeda Hira Tahir   +4 more
doaj   +1 more source

Mapping Steroidogenic Perturbations Under Endocrine Disruptor Mixtures Across Demographic Subgroups: Structural and Metabolomic Insights

Advanced Science, EarlyView.
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen, Lei Huang, Yingtong Jiang, Guohong Zhao, Mengyuan Zhu, Xiulian Lu, Lang Lang, Akinpelumi Oluwatobiloba Esther, Longhao Fan, Yuqi Jiang, Chang Sun, Xiaoling Zhang, Kun Zhou, Xiaoming Ji, Minjian Chen   +14 more
wiley   +1 more source

Atherogenic ApoB-dyslipidemia, atherosclerotic cardiovascular disease, cardiac dysfunction and remodeling in high-risk young women with and without polycystic ovary syndrome: A pilot study

Frontiers in Endocrinology
IntroductionPolycystic ovary syndrome (PCOS) is associated with increased cardiometabolic risk in young women of reproductive age. There are limited studies on atherogenic dyslipidemia, inclusive of triglycerides (TG), Apolipoprotein (apo) B-lipoproteins
Xiaoying Wu, Mich Wilke, Jesse Batara, Spencer Proctor, Melanie Cree, Mahua Ghosh, Paolo Raggi, Jonathon Windram, Harald Becher, Donna Vine, Donna Vine, Donna Vine   +11 more
doaj   +1 more source

PCOS in adolescents

Best Practice & Research Clinical Obstetrics & Gynaecology, 2010
Polycystic ovary syndrome (PCOS), a heterogeneous syndrome of unknown aetiology, is the leading cause of anovulation, hirsutism and infertility in women. This multifactorial syndrome emerges at puberty and has cardiovascular and metabolic sequelae through menopause.
openaire   +3 more sources

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Myo-Inositol and Its Derivatives: Their Roles in the Challenges of Infertility

Biology
Myo-inositol (MYO) and D-chiro-inositol (DCI) are the two most significant isomeric forms of inositol, playing a critical role in intracellular signaling. MYO is the most abundant form of inositol in nature; DCI is produced from MYO through epimerization
Martina Placidi, Giovanni Casoli, Carla Tatone, Giovanna Di Emidio, Arturo Bevilacqua   +4 more
doaj   +1 more source

The Comparison of the Effects of Voluntary Running Wheel and Endurance Training on Il-6 and Testosterone Levels in the Rats With PCOS

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2021
Background and Aim: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder in women of reproductive age. In cross-sectional and longitudinal studies, exercise training is an effective solution for treating and declining the symptoms.
Faranak Moradi, Ali Akbarnejad
doaj