Results 81 to 90 of about 3,764,452 (295)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Kanser Hastalarında COVID-19 Bilgisayarlı Tomografi, Klinik ve Laboratuvar Bulgularının Değerlendirilmesi

Düzce Tıp Fakültesi Dergisi, 2020
Amaç: Bu çalışmanın amacı kanser hastalarında koronavirus hastalığı 2019 (coronavirus disease 2019, COVID-19) bilgisayarlı tomografi (BT), klinik ve laboratuvar bulgularının değerlendirilmesi ve polimeraz zincir reaksiyonu (polymerase chain reaction, PCR)
Tolga Köşeci̇, Ömer Kaya, Okan Di̇lek, İ̇rfan Ali̇şan, Veysel Haksöyler, Berna Bozkurt Duman, Timuçin Çi̇l   +6 more
doaj   +1 more source

Learning-based constraints on schemata [PDF]

, 2000
Schemata are frequently used in cognitive science as a descriptive framework for explaining the units of knowledge. However, the specific properties which comprise a schema are not consistent across authors. In this paper we attempt to ground the concept
Cheng, PCH, Gobet, F, Lane, PCR
core   +1 more source

Bayesian estimation of diagnostic accuracy of fecal culture and PCR-based tests for the detection of Salmonella enterica in California cull dairy cattle. [PDF]

, 2020
Epidemiological studies of low prevalence disease problems are often hindered by the high cost of diagnostic testing. The objective of this study was to evaluate PCR screening of both individual and pooled fecal samples from culled dairy cows for the ...
Adaska, John M, Aly, Sharif S, Atwill, Edward R, Clothier, Kristin A, Ekong, Pius S, Lehenbauer, Terry W, Li, Xunde, Rossitto, Paul V, Williams, Deniece R   +8 more
core   +1 more source

HER2 and ESR1 mRNA expression levels and response to neoadjuvant trastuzumab plus chemotherapy in patients with primary breast cancer [PDF]

, 2013
Introduction: Recent data suggest that benefit from trastuzumab and chemotherapy might be related to expression of HER2 and estrogen receptor (ESR1). Therefore, we investigated HER2 and ESR1 mRNA levels in core biopsies of HER2-positive breast carcinomas
A Goldhirsch, A Hurtado, A Noske, AA Lazar, AC Wolff, Andre Robidoux, BM Müller, Bruno V Sinn, C Denkert, Carsten Denkert, Christine Solbach, CK Osborne, D Slamon, DG Altman, DJ Dabbs, EA Perez, EH Romond, FL Baehner, G Hennig, G Konecny, G Pentheroudakis, G von Minckwitz, G von Minckwitz, G von Minckwitz, Gunter von Minckwitz, H Joensuu, Hans Tesch, I Pinhel, J Baselga, J Baselga, Jan C Brase, Jens Huober, Judith Prinzler, K Bohmann, Keyur Mehta, Knut Engels, L Gianni, L Gianni, LM McShane, M Bonetti, M Dowsett, M Dowsett, M Filipits, M Untch, M Untch, M Untch, M Untch, Martin-Leo Hansmann, Mattea Reinisch, ME Hammond, Michael Untch, MJ Piccart-Gebhart, MP Fereshteh, PC Roche, Peter A Fasching, Ralf Kronenwett, S Johnston, S Paik, S Paik, Sibylle Loibl, Silvia Darb-Esfahani, T Lahusen, W Zhao   +62 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Flexible methods for uncertainty estimation of digital PCR data

iScience
Summary: Digital PCR (dPCR) is an accurate technique for quantifying nucleic acids, but variance estimation remains a challenge due to violations of the assumptions underlying many existing methods.
Yao Chen, Ward De Spiegelaere, Matthijs Vynck, Wim Trypsteen, David Gleerup, Jo Vandesompele, Olivier Thas   +6 more
doaj   +1 more source

Comparison of methods for in-house screening of HLA*B57:01 to prevent abacavir hypersensitivity in HIV-1 care [PDF]

, 2015
Abacavir is a nucleoside reverse transcriptase inhibitor used as part of combination antiretroviral therapy in HIV-1-infected patients. Because this drug can cause a hypersensitivity reaction that is correlated with the presence of the HLA-B*57:01 ...
Bonczkowski, Pawel, Callens, Steven, Coucke, Paul, De Spiegelaere, Ward, De Wit, Stephane, Emonds, Marie-Paule, Kabeya, Kabamba, Kiselinova, Maja, Malatinková, Eva, Philippé, Jan, Ruelle, Jean, SERMIJN, ERICA, Trypsteen, Wim, Van Acker, Petra, Van Sandt, Vicky, Vandekerckhove, Linos, Verhofstede, Chris, VERVISCH, KAREN, Vogelaers, Dirk   +18 more
core   +4 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Under pressure: How time-limited cognition explains statistical learning by 8-month old infants [PDF]

, 2016
In a classic experiment, Saffran, Aslin, and Newport (1996)used a headturn preference procedure to show that infants candiscriminate between familiar syllable sequences (“words”)and new syllable sequences (“non-words” and “part-words”).While several ...
Gobet, FR, Lane, PCR, Lloyd-Kelly, M
core