Results 81 to 90 of about 3,284,156 (346)
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Revista X, 2017 Neste trabalho, apresentamos os resultados de uma entrevista realizada com a Professora Dr.ª Lívia Suassuna. Essa entrevista traz à diversos aspectos atinentes ao trabalho pedagógico do ensino da produção de texto, tais como: os contributos dos ...
Silvio Profirio da Silva +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
Reducing the Effects of PCR Amplification and Sequencing Artifacts on 16S rRNA-Based Studies
PLoS ONE, 2011 The advent of next generation sequencing has coincided with a growth in interest in using these approaches to better understand the role of the structure and function of the microbial communities in human, animal, and environmental health.
P. Schloss, D. Gevers, Sarah L. Westcott
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
BMC Global and Public HealthBackground The Philippines’ high tuberculosis (TB) burden calls for effective point-of-care screening. Systematic TB case finding using chest X-ray (CXR) with computer-aided detection powered by deep learning-based artificial intelligence (AI-CAD ...
Nichel Marquez +6 more
doaj +1 more source
Scientific Reports, 2018 Single cell genome analysis methods are powerful tools to define features of single cells and to identify differences between them. Since the DNA amount of a single cell is very limited, cellular DNA usually needs to be amplified by whole-genome ...
Christiane Bäumer +4 more
doaj +1 more source
Molecular Oncology, EarlyView.mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo +8 more
wiley +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number
Analytical Chemistry, 2011 Digital PCR enables the absolute quantitation of nucleic acids in a sample. The lack of scalable and practical technologies for digital PCR implementation has hampered the widespread adoption of this inherently powerful technique. Here we describe a high-
B. Hindson +37 more
semanticscholar +1 more source