Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Introduction. Hepatitis B virus (HBV) infection in hemodialysis (HD) patients is a major concern, but limited information exists on the HBV genotyping in patients on maintenance HD in Turkey.Aim.
Murat Sayan, M.D., Cengiz Dogan
doaj +1 more source
Towards a model of expectation-driven perception [PDF]
Human perception is an active process by which meaningful information is gathered from the external environment. Application areas such as human-computer interaction (HCI), or the role of human experts in image analysis, highlight the need to ...
Gobet, F, Lane, PCR
core
Microfluidic DNA amplification - a review [PDF]
The application of microfluidic devices for DNA amplification has recently been extensively studied. Here, we review the important development of microfluidic polymerase chain reaction (PCR) devices and discuss the underlying physical principles for the ...
Ozdemir, Pinar, Zhang, Yonghao
core +1 more source
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Computational models of the development of perceptual expertise [PDF]
In a recent article, Palmeri, Wong and Gauthier have argued that computational models may help direct hypotheses about the development of perceptual expertise.
Campitelli, G, Gobet, F, Lane, PCR
core
Bayesian estimation of diagnostic accuracy of fecal culture and PCR-based tests for the detection of Salmonella enterica in California cull dairy cattle. [PDF]
Epidemiological studies of low prevalence disease problems are often hindered by the high cost of diagnostic testing. The objective of this study was to evaluate PCR screening of both individual and pooled fecal samples from culled dairy cows for the ...
Adaska, John M +8 more
core +1 more source
ThermoPhyl : a software tool for selecting phylogenetically optimized conventional and quantitative-PCR taxon-targeted assays for use with complex samples [PDF]
The ability to specifically and sensitively target genotypes of interest is critical for the success of many PCR-based analyses of environmental or clinical samples that contain multiple templates.Next-generation sequence data clearly show that such ...
Dowd, Scot E. +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
MOLECULAR DETECTION OF TEM GENE IN ESCHERICHIA COLI O157:H7 ISOLATED FROM CHILDREN AND BUFFALOES IN BASRAH PROVINCE [PDF]
During a period of five months (August 2015 to December 2015), a total of 250 samples werecollected 125 from hospitalized children suffering from diarrhea, and 125 from buffalo feces samplescollected from different regions in Basra Province, (Basra City ...
Raneem A. Kareem, Bassam Y. Khudaier
doaj +1 more source

