Results 111 to 120 of about 40,685 (224)

Contrasting effects of intracellular and extracellular human PCSK9 on inflammation, lipid alteration and cell death

Communications Biology
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is one of the major regulators of low-density lipoprotein receptor (LDLR). Information on role and regulation of PCSK9 in lung is very limited.
Aram Ghalali, Fahd Alhamdan, Swapna Upadhyay, Koustav Ganguly, Kjell Larsson, Lena Palmberg, Mizanur Rahman   +6 more
doaj   +1 more source

STATINS, BUT NOT PCSK9 INHIBITORS, REDUCE THE ADIPOKINE CHEMERIN IN FAMILIAL HYPERCHOLESTEROLEMIA: FOCUS ON LIPOPROTEIN SUBFRACTIONS

, 2022
Lunbo Tan, Na Wang, Leonie Van Vark Van Der Zee, Jeanine E. Roeters van Lennep, Monique T. Mulder, Xifeng Lu, A.H. Jan Danser, Koen Verdonk   +7 more
openalex   +2 more sources

Course of Pregnancy in a Woman With Familial Chylomicronemia Syndrome Treated With Plozasiran, a Small Interfering RNA Against ApoC3

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Persistent chylomicronemia is associated with severe hypertriglyceridemia (sHTG) and plasma triglycerides (TG) levels sustainably > 10 mmol/L (880 mg/dL) despite lipid lowering therapies. The main risk of persistent chylomicronemia is acute pancreatitis (AP). During the second and third trimester of pregnancy, TG levels significantly increase,
Miriam Larouche, Diane Brisson, Nathalie Roy, Claudy Grenon, Paul Poirier, Ma'an Muhsin, Daniel Gaudet   +6 more
wiley   +1 more source

Südame isheemiatõve riski ennustamine geneetiliste markerite abil [PDF]

, 2015
Südame isheemiatõbi on komplekshaigus, mille avaldumises on roll keskkonnal, eluviisil, pärilikkusel ja nende koosmõjudel. Haiguse tekkeriski võimalikult varajane ja täpne hindamine on ennetava ravi määramise nurgakiviks.
Ainla, Tiia, Alver, Maris, Eha, Jaan, Fischer, Krista, Marandi, Toomas, Saar, Aet   +5 more
core   +2 more sources

Emerging low-density lipoprotein therapies: Targeting PCSK9 for low-density lipoprotein reduction [PDF]

, 2013
Michael H. Davidson
openalex   +1 more source

Breast Cancer: Molecular Pathogenesis, Targeted Therapy, Screening, and Prevention

MedComm, Volume 7, Issue 1, January 2026.
The review manuscript examines the molecular pathogenesis, screening, prevention advances, and evolving targeted therapies in breast cancer. It highlights the integration of AI and multiomics for precision prevention and personalized treatment, pointing toward future directions in equitable cancer care.
Huijun Lei, Jinzhen Fu, Wei Gu, Hongjin Qiao, Huixue Guo, Zijian Chen, San Ming Wang, Tianhui Chen   +7 more
wiley   +1 more source

Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents

Lipids in Health and Disease, 2011
Background During the past decade, proprotein convertase subtilisin kexin type 9 (PCSK9) has been identified as a key regulator of serum LDL-cholesterol (LDL-C) levels.
Troutt Jason S, Konrad Robert J, Cao Guoqing   +2 more
doaj   +1 more source

Epiafzelechin, a Flavanol, Regulates Lipid Homeostasis Through Modulation of HMGCR, PCSK9, and PPAR‐α: Mechanistic Insights and Therapeutic Implications [PDF]

Cardiovasc Ther
Hyperlipidemia remains a leading modifiable risk factor for cardiovascular morbidity and mortality. Statins are considered the cornerstone of treatment; however, their adverse effects and limited efficacy in certain patient populations necessitate exploration of novel therapeutic avenues. Epiafzelechin (EZN), a flavanol with established antioxidant and
Alshammari S, Shahzad N, Malik M, Alshammari Q, Alshammari A, Al Kazman B, Atif M, Solre G.   +7 more
europepmc   +2 more sources

Hepatitis C virus relies on lipoproteins for its life cycle [PDF]

, 2016
Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma.
Alonzi, Tonino, DI CAPRIO, Giorgia, Fimia, Gian Maria, Grassi, Germana, Ippolito, Giuseppe, Tripodi, Marco   +5 more
core   +1 more source

Real-world use of PCSK9 inhibitors: A single-center experience [PDF]

, 2018
Sinan Sarsam, Abeer Berry, George Degheim, Robby Singh, Marcel Zughaib   +4 more
openalex   +1 more source