Results 191 to 200 of about 40,773 (330)
Obesity Reviews, EarlyView.Summary With the evolving landscape of diseases, heart failure with preserved ejection fraction (HFpEF) now encompasses more than half of all heart failure patients. This condition is clinically diverse, involving multiple organ systems and often occurring alongside the aging process.
Zhongwen Qi +6 more
wiley +1 more source
Functional analysis of sites within PCSK9 responsible for hypercholesterolemia [PDF]
, 2008 Shilpa Pandit +10 more
openalex +1 more source
Atopic Status Is Associated With Kidney Transplanted Recipients' Outcomes
Allergy, EarlyView.
Luc Colas +27 more
wiley +1 more source
The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase
Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.ABSTRACT Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) plays an essential role in the maintenance of vascular homeostasis and the prevention of vascular inflammation. There are a myriad of mechanisms that regulate the activity of the enzyme that may prove to represent interesting therapeutic opportunities.
Riham Rafea +2 more
wiley +1 more source
Self-Association of Human PCSK9 Correlates with Its LDLR-Degrading Activity [PDF]
, 2008 Daping Fan +6 more
openalex +1 more source
Diabetes, Obesity and Metabolism, Volume 27, Issue 5, Page 2573-2583, May 2025.Abstract Background and Aims Adequate lipid control has emerged as a key factor in the prevention and management of chronic kidney disease (CKD). Remnant cholesterol (RC), a lipoprotein with an established association with cardiovascular risk, has been investigated in the context of CKD.
Paschalis Karakasis +4 more
wiley +1 more source
Functional analysis of sites within PCSK9 responsible for hypercholesterolemias⃞
Journal of Lipid Research, 2008 Mutations within proprotein convertase subtilisin/kexin type 9 (PCSK9) are associated with dominant forms of familial hypercholesterolemia. PCSK9 binds the LDL receptor (LDLR), and addition of PCSK9 to cells promotes degradation of LDLR.
Shilpa Pandit +10 more
doaj
Variation in PCSK9, low LDL cholesterol, and risk of peripheral arterial disease [PDF]
, 2008 Aaron R. Folsom +2 more
openalex +1 more source
Advancing Precision Medicine: Recent Innovations in Gene Editing Technologies
Advanced Science, Volume 12, Issue 14, April 10, 2025.This review article delves into the cutting‐edge advancements in gene editing technology, with a particular focus on prime editor proteins and their engineered variants. The authors provide a thorough examination of recent developments that have addressed key challenges in the field, including improved precision, enhanced editing efficiency, and ...
Abhijith Koodamvetty +1 more
wiley +1 more source
A new method for measurement of total plasma PCSK9: clinical applications [PDF]
, 2009 Geneviève Dubuc +10 more
openalex +1 more source