Results 101 to 110 of about 264,642 (338)

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

Alterations of immune response of non-small lung cancer with azacytidine [PDF]

, 2013
Innovative therapies are needed for advanced Non-Small Cell Lung Cancer (NSCLC). We have undertaken a genomics based, hypothesis driving, approach to query an emerging potential that epigenetic therapy may sensitize to immune checkpoint therapy targeting
Baylin, Stephen B, Brahmer, Julie R, Brock, Malcolm V, Carvajal, Richard D, De Meyer, Tim, Du, Zhengzong, Easton, Keith, Easwaran, Hariharan, Jones, Peter A, Juergens, Rosalyn A, Koch, Alexander, Laird, Peter W, Mohammad, Helai P, Pardoll, Drew, Parsana, Princy, Rodgers, Kristen, Rudin, Charles M, Taube, Janis M, Topalian, Suzanne L, Tsai, Salina, Tykodi, Scott S, Van Criekinge, Wim, Vendetti, Frank, Wang, Wei, Weisenberger, Daniel J, Wrangle, John, Yen, Ray-Whay, Zahnow, Cynthia A   +27 more
core   +1 more source

The current status of checkpoint inhibitors in metastatic bladder cancer [PDF]

, 2016
For many decades, no significant improvements could be achieved to prolong the survival in metastatic bladder cancer. Recently, systemic immunotherapy with checkpoint inhibitors (anti-PD-L1/anti-CTLA-4) has been introduced as a novel treatment modality ...
Fahmy Ahmed, Omar Ahmed, Gakis, Georgios, Mohd. Ghani @ Mamat, Khairul Asri, Stenzl, Arnulf   +3 more
core   +1 more source

Noninvasive Imaging of Tumor PD-L1 Expression Using Radiolabeled Anti–PD-L1 Antibodies [PDF]

Cancer Research, 2015
Abstract Antibodies that block the interaction between programmed death ligand 1 (PD-L1) and PD-1 have shown impressive antitumor activity. Patients with tumors expressing PD-L1 are most likely to respond to this treatment. The aim of our study was to develop a noninvasive imaging technique to determine tumor PD-L1 expression in vivo ...
Heskamp, S., Hobo, W.A., Molkenboer-Kuenen, J.D.M., Molkenboer-Kuenen, J.D.M., Olive, D., Oyen, W.J.G., Dolstra, H., Boerman, O.C.   +7 more
openaire   +4 more sources

Metal Nanoclusters for Cancer Imaging and Treatment

Advanced Functional Materials, EarlyView.
This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu, Ziping Wang, Qiaofeng Yao, Ping Zhang, Jianping Xie, Xun Yuan   +5 more
wiley   +1 more source

Functional Expression of Programmed Death-Ligand 1 (B7-H1) by Immune Cells and Tumor Cells

Frontiers in Immunology, 2017
The programmed death-1 (PD-1) and its ligand PD-L1 (B7-H1) signaling pathway has been the focus of much enthusiasm in the fields of tumor immunology and oncology with recent FDA approval of the anti-PD-1 antibodies pembrolizumab and nivolumab and the ...
Rachel M. Gibbons Johnson, Haidong Dong, Haidong Dong   +2 more
doaj   +1 more source

Control of pathogenic effector T-cell activities in situ by PD-L1 expression on respiratory inflammatory dendritic cells during respiratory syncytial virus infection [PDF]

, 2015
Respiratory syncytial virus (RSV) infection is a leading cause of severe lower respiratory tract illness in young infants, the elderly and immunocompromised individuals.
Braciale, T. J., Davis, S. D., Du, J., Jewett, L. B., Jiang, L., Krupp, N. L., Moser, E. K., Sun, J., Wright, J., Yao, S., Zhou, B.   +10 more
core   +1 more source

Integrated Metallo‐Dielectric 3D Hotspots From High Refractive Index Nanodiamond‐Plasmonic Gold Cryosoret Nano‐Assemblies for Photonic Crystal Enhanced Fluorescence

Advanced Functional Materials, EarlyView.
This work presents a novel sensing platform using metallo‐dielectric cryosoret nano‐assemblies and lossless photonic crystals to overcome limitations of conventional plasmonic biosensors. The hybrid system enhances both electric and magnetic field interactions, enabling amplified fluorescence, ultralow detection limits, and prism‐free, objective‐free ...
Seemesh Bhaskar, Weinan Liu, Skye Shepherd, Devinda Wijewardena, Joseph Tibbs, Brian T. Cunningham   +5 more
wiley   +1 more source

TLR9 Mediated Tumor-Stroma Interactions in Human Papilloma Virus (HPV)-Positive Head and Neck Squamous Cell Carcinoma Up-Regulate PD-L1 and PD-L2 [PDF]

, 2019
Background: The co-inhibitory receptor PD-1 is expressed in many tumors including head and neck squamous cell carcinoma (HNSCC) and is an important immunotherapy target.
Ahmadzadeh, Albers, Ansell, Baruah, Brahmer, Ceeraz, Dong, Forster, Gameiro, Gao, George, Gursel, Hamid, Hino, Howitt, Junttila, Kaminski, Kataoka, Kawai, Kiemer, Konishi, Krieg, Kuznik, Lastwika, Loi, Lyford-Pike, Nazareth, Nguyen, Nishimura, O'mahony, Okazaki, Pai, Pinchuk, Raposo, Saada-Bouzid, Strome, Topalian, Topalian, Velcheti, Venuti, Wilke, Wintterle, Wolchok, Wolfle, Yearley, Zou   +45 more
core   +1 more source

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, EarlyView.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source