Results 141 to 150 of about 264,642 (338)

Moving forward to address key unanswered questions on targeting PD-1/PD-L1 in cancer: limitations in preclinical models and the need to incorporate human modifying factors. [PDF]

, 2019
The tremendous clinical success of immune checkpoint inhibition (ICI), particularly targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1/2 (PD-L1/2) pathway, has resulted in application to multiple cancers, as a monotherapy and ...
Le, Catherine T, Murphy, William J
core   +1 more source

Mechanically Compliant and Optically Tunable Metal Oxide‐PDMS Nanocomposite Thin Films as a Platform for Flexible Photonic Integration

Advanced Materials Interfaces, EarlyView.
This study demonstrates polydimethylsiloxane (PDMS) nanocomposite thin films incorporating ZnO and TiO2 nanoparticles, optimized using response surface methodology. The films exhibit tunable refractive index, high transparency, low optical loss, and sub‐MPa mechanical compliance.
Moqaddaseh Afzali Naniz, Amr Al Abed, Danyang Wang, Nigel Hamilton Lovell, Dorna Esrafilzadeh   +4 more
wiley   +1 more source

Concordance among four commercially available, validated programmed cell death ligand-1 assays in urothelial carcinoma

Diagnostic Pathology, 2019
Background Antibodies targeting the programmed cell death-1 (PD-1)/PD-ligand 1 (PD-1/PD-L1) checkpoint have shown promising clinical activity in patients with advanced urothelial carcinoma (UC).
Magdalena Zajac, Marietta Scott, Marianne Ratcliffe, Paul Scorer, Craig Barker, Hytham Al-Masri, Marlon C. Rebelatto, Jill Walker   +7 more
doaj   +1 more source

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8⁺ T cell activation and cytolysis [PDF]

, 2003
Nancy Rodig, Timothy A. Ryan, Jessica A. Allen, Hong Pang, Nir Grabie, Tatyana Chernova, Edward Greenfield, Spencer C. Liang, Arlene H. Sharpe, Andrew H. Lichtman, Gordon J. Freeman   +10 more
openalex   +1 more source

Photonic Crystal Enhanced Microscopy on a 2D Photonic Crystal Surface

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This work demonstrates the design, fabrication, and the first‐time test of a 2D photonic crystal surface for photonic resonator absorption microscopy. The designed surface uniformly enhances electromagnetic near fields, achieving > 100% improved detecting uniformity for surface‐captured AuNPs from a blocking biosensor assay aimed for detecting SARS‐CoV‐
Weinan Liu, Siyan Li, Edmond Chow, Seemesh Bhaskar, Ying Fang, Brian T. Cunningham   +5 more
wiley   +1 more source

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Advanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu, Jingyi Liu, Wei Qin, Chengsheng Ding, Zhenghao Cai, Duohuo Shu, Hao Zhong, Yanyan Hu, Mengqin Yu, Leqi Zhou, Jianwen Li, Minhua Zheng, Bin Li, Sen Zhang, Xiao Yang, Bo Feng   +15 more
wiley   +1 more source

CCL5hi Macrophages Interact with CD8+ T Cells and Potentiate Responsiveness to PD‐1 Blockade Plus Chemotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study has characterized a functionally distinct macrophage subset, termed CCL5hi macrophages, and elucidated the underlying mechanisms of a regulatory feedback loop that interconnects IFN‐γ, CCL5hi macrophages, and CD8+ T cells within the TME of ESCC undergoing immunochemotherapy.
Yuanzhen Ma, Xiaodong Su, Tingting Zeng, Chunlian Zhou, Guozhen Yang, Zengfei Xia, Chufeng Zeng, Jiarong Zhan, Xin‐Yuan Guan, Xu Zhang, Yan Li   +10 more
wiley   +1 more source

Blockade of PD‐L1 (B7‐H1) augments human tumor‐specific T cell responses in vitro [PDF]

, 2006
Christian U. Blank, Juergen Kuball, Simon Voelkl, Heinz Wiendl, Bernd Becker, Bernhard Walter, Otto Majdic, Thomas F. Gajewski, M. Theobald, Reinhard Andreesen, Andréas Mackensen   +10 more
openalex   +1 more source

272 PD-L1 CAR engineered K-NK cells to target PD-L1⁺or PD-L1^-tumors

Regular and Young Investigator Award Abstracts, 2023
Pedro Romero, Andre Kunert, Hardikkumar Jetani, Katarzyna Franciszkiewicz, David Vlerick, Aleksandra Nowicka, Robert Y Igarashi   +6 more
openaire   +2 more sources

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source